Deatailed information for cohesin site CDBP00421624

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  • Basic information
  • CohesinDB ID: CDBP00421624
  • Locus: chr21-46634382-46636748
  • Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, GSE120943, ENCSR198ZYJ, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE76893, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, ENCSR217ELF, GSE131956, GSE110061, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, GSE98367, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE62063, ENCSR807WAC, ENCSR981FDC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR153HNT, GSE68388, GSE126990
  • Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, Macrophage, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, Neutrophil, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 47% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.300
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: False Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 86% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "2_TssAFlnk": 30%, "1_TssA": 27%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, IKZF3, MORC2, PAX5, SFPQ, TEAD1, ZNF121, SNAPC1, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, POU2F1, E4F1, ARID5B, SOX5, PAX8, DEK, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, BRD3, POU5F1, TOP2A, ZNF263, CTBP1, ZMYND11, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, FOXK2, UBN1, RCOR1, NR2F6, NFRKB, CD74, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ELF4, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, HCFC1, MXI1, ZNF785, RELB, EP400, RUVBL2, RUNX1, HDAC1, NKX2-2, CEBPA, CRY1, ZNF707, REPIN1, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ELK1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, GSPT2, IKZF5, ARID2, AFF1, MBD2, ELL2, NFATC3, CBFA2T2, ZNF207, CBX3, CREM, CHD2, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, SRSF4, HNRNPK, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, TP63, ZSCAN4, MITF, INTS11, JMJD1C, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, TAF3, CTCF, L3MBTL4, LMO1, ZBTB20, MNT, DPF2, RYBP, IRF4, PDX1, RBPJ, TFAP2C, MLX, ZNF239, MTA2, ZBTB17, ZBTB48, ZSCAN21, ZNF317, NONO, SRF, NBN, PBX1, KDM4A, HOMEZ, FOXP2, ZNF2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, CTNNB1, ZBTB24, LDB1, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, DAXX, ARNT, NFIB, BACH1, ZNF48, ZEB2, HMBOX1, NFYA, PBX3, MAFB, NCAPH2, ZNF10, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, GLIS2, PRDM6, ZNF623, SMC3, MLLT1, STAG1, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, KLF7, KDM1A, BCL3, ZNF222, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, MTA1, AGO2, TP53, ZNF645, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, JUND, BRD4, CUX1, ZSCAN23, PGR, SOX2, PATZ1, SNAPC4, LEO1, UBTF, TFAP4, SIN3B, SETX, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, ZNF524, KLF1, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, ZNF24, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, INO80, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, TAF9B, ZNF76, NCOA2, ETV5, BCL6, SIN3A, ERG3, CREBBP, ZNF384, NFYC, RARA, TAF15, ZNF35, ZNF518A, SMAD4, CDK8, CSNK2A1, ZEB1, SUPT16H, NCOA1, SREBF2, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF574, TCF7, FOXO3, RELA, TARDBP, CHAMP1, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, PAX3-FOXO1, KMT2D, YAP1, ZNF324, HEXIM1, AHR, DMAP1, MBD3, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, KLF5, THRAP3, BCLAF1, TRIM28, ETV1, RCOR2, USF2, TCF12, EP300, BAF155, GATA6, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, MLLT3, GATAD1, GMEB2, ARID3A, ASCL1, USP7, ZNF341, MIER1, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, TCF25, ZNF639, ARNTL, ZNF501, JMJD6, FEZF1, TFE3, ZNF664, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, MYF5, ATF1, CBX1, SMC1A, MAFG, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, NMYC, TWIST1, IRF2, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, NRF1, NR2C1, SUPT5H, CHD1, FOS, TGIF2, MED1, ZNF558, MYB, CEBPD, KDM6B, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, NELFA, ZNF283, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, HIF1A, OTX2, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, ZNF213, ZNF843, BHLHE40, NFKBIZ, TAF1, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, BRCA1
  • Target gene symbol (double-evidenced CRMs): S100B,PRMT2,LSS,MCM3AP-AS1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 32
  • Number of somatic mutations (non-coding): 10
  • Related genes and loops
  • Related gene: ENSG00000160285, ENSG00000215424, ENSG00000160307, ENSG00000160310,
  • Related loop: chr21:46143023-46144677~~chr21:46639346-46640584, chr21:46152495-46154271~~chr21:46639226-46640751, chr21:46224751-46225933~~chr21:46639346-46640584, chr21:46226574-46227839~~chr21:46635152-46636811, chr21:46550822-46552528~~chr21:46639252-46640633, chr21:46598388-46600289~~chr21:46634449-46636635, chr21:46621725-46623434~~chr21:46635155-46636377,
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