- Basic information
- CohesinDB ID: CDBP00421636
- Locus: chr21-46660252-46664093
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE131606, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE165895, ENCSR000BKV, GSE115250, GSE122299, GSE138405, GSE67783, GSE86191, GSE76893, GSE101921, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE145327, GSE93080, GSE118494, GSE115248, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, GSE206145, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, ENCSR054FKH, ENCSR153HNT, GSE126990, GSE50893, GSE131577
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Cell type: MDM, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, TC-32, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, Kelly, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, GM18505, Lymphoblast, GM12878, GM12891, GM2588, HUES9, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, HCAEC, GM19238, TC-71, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 37% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.456
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 39%,
"4_Tx": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, ZSCAN5C, XBP1, FOXA1, RBFOX2, LEO1, ZNF28, ZFHX2, HNRNPK, ATF3, RUNX3, ZNF444, CBFB, SMARCE1, PAX5, TP63, MITF, ELF1, TRIM28, TEAD1, BCLAF1, SNAI2, RBM39, LMO2, ESR1, ZNF217, TP73, CTCF, TCF12, JUN, KLF1, LMO1, MNT, RYBP, DPF2, E2F6, IRF4, RFX5, E2F1, SMC1, TEAD4, GTF2F1, TFAP2C, EED, JARID2, NANOG, POU2F2, CHD8, ZSCAN5D, POU5F1, MYCN, RUNX1T1, CDK7, ZNF263, BRD1, ZBTB48, ZSCAN5A, STAT1, SRF, ERG2, ERG, OGG1, ETS1, MYC, SMARCA4, KDM4A, RAD21, FOXP2, GRHL3, RXRA, GABPA, STAT3, PRDM14, IKZF1, NFE2, HNRNPH1, RCOR1, DNMT3B, NR3C1, CEBPB, HNRNPL, KMT2A, CREB1, EZH2, GRHL2, GABPB1, ZHX2, ZBTB14, HDAC2, GATAD2B, MXD3, FLI1, HCFC1, DRAP1, MXI1, SMARCA5, HCFC1R1, MRTFB, PTBP1, RUNX1, AHRR, SMC1A, CBX1, BCL6, NKX2-2, SIRT6, SIN3A, ZFX, POU4F2, SMAD3, TET2, ERG3, TRIM22, SMARCC1, TWIST1, ZBTB2, CREBBP, NOTCH1, RARA, RUNX2, SMAD2, ARNT, BACH1, TFDP1, ELK1, NRF1, ATF2, PRDM9, SMAD4, ZBTB10, PBX3, NCAPH2, CHD1, CDK8, FOS, MED1, ZEB1, MYB, SMAD1, TAF7, ZNF3, RBM22, BCL11A, NIPBL, NR4A1, REST, ASH2L, HNRNPLL, CTBP2, TCF3, FOXP1, BCOR, MBD2, AATF, SMC3, ELL2, STAG1, STAG2, CXXC4, TRP47, FOXA2, AGO1, CREM, EBF1, PAF1, HDAC6, SS18, ZNF600, WT1, ZBTB33, CDK9, KDM1A, YY1, RELA, TARDBP, NEUROD1, BRG1, SP140, HIF1A, PCGF1, OTX2, GATA3, ZNF519, BATF, TAL1, MAX, NRIP1, ZNF143, AGO2, MTA1, HAND2, KLF4, ZNF141, NR2F2, NR2F1, TCF7L2, KDM5B, NEUROG2, TP53, ZBTB6, NFKB1, MYOD1, EGR2, BRD2, RBM14, TBX21, BHLHE40, AR, TAF1, RXR, EGR1, RB1, TFIIIC, ZBTB26, HSF1, HEXIM1, BRD4, JUND, CUX1, MAZ, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): PRMT2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 728
- Number of somatic mutations (non-coding): 104
- Related genes and loops