Deatailed information for gene ENSG00000154654
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00009786
- Gene Symbol: NCAM2
- Ensembl ID: ENSG00000154654
-
Gene locus: chr21:20998408-21543329
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs
- Regulatory cohesin (double-evidenced):
chr21-20424901-20426146,
chr21-20432865-20433818,
chr21-20442946-20444250,
chr21-20826778-20827091,
chr21-20832771-20833112,
chr21-20834445-20834555,
chr21-20995322-20995464,
chr21-20995936-20996190,
chr21-20996658-21002798,
chr21-21003129-21004886,
chr21-21007581-21007949,
chr21-21015702-21015894,
chr21-21027981-21029993,
chr21-21030291-21030686,
chr21-21032476-21032704,
chr21-21042472-21042822,
chr21-21045765-21046419,
chr21-21049004-21049207,
chr21-21051098-21051509,
chr21-21051826-21052767,
chr21-21056251-21057044,
chr21-21061987-21065549,
chr21-21068378-21068593,
chr21-21071924-21072263,
chr21-21074130-21074488,
chr21-21077472-21078066,
chr21-21088665-21089593,
chr21-21090443-21090681,
chr21-21092269-21092950,
chr21-21096695-21097509,
chr21-21100399-21100862,
chr21-21101078-21103497,
chr21-21116519-21116876,
chr21-21119737-21119875,
chr21-21120733-21121106,
chr21-21123099-21123338,
chr21-21139693-21140229,
chr21-21142400-21142728,
chr21-21146615-21147464,
chr21-21155794-21156222,
chr21-21162657-21165885,
chr21-21166187-21166468,
chr21-21167551-21167749,
chr21-21173598-21174301,
chr21-21175106-21175962,
chr21-21176166-21176643,
chr21-21176999-21177311,
chr21-21178608-21178796,
chr21-21179659-21180419,
chr21-21193044-21193804,
chr21-21195369-21196392,
chr21-21196698-21197595,
chr21-21197796-21198434,
chr21-21199016-21199562,
chr21-21199812-21201721,
chr21-21202488-21202681,
chr21-21210924-21211070,
chr21-21216013-21216816,
chr21-21230014-21230340,
chr21-21230579-21234343,
chr21-21235995-21236343,
chr21-21237497-21237840,
chr21-21238208-21240548,
chr21-21242043-21242230,
chr21-21244524-21244882,
chr21-21247060-21248771,
chr21-21255359-21255845,
chr21-21258567-21259118,
chr21-21259876-21260008,
chr21-21267722-21270230,
chr21-21272430-21272627,
chr21-21272934-21273037,
chr21-21275136-21275450,
chr21-21279423-21279886,
chr21-21281785-21282531,
chr21-21282843-21283092,
chr21-21283545-21284157,
chr21-21286065-21286863,
chr21-21288600-21288861,
chr21-21290793-21291170,
chr21-21292007-21292528,
chr21-21295412-21295555,
chr21-21296881-21297766,
chr21-21300755-21301299,
chr21-21311331-21311658,
chr21-21312042-21312462,
chr21-21315193-21315849,
chr21-21319246-21320011,
chr21-21323820-21324668,
chr21-21327018-21327261,
chr21-21331740-21332194,
chr21-21332677-21332848,
chr21-21335462-21336404,
chr21-21337493-21337886,
chr21-21339567-21341001,
chr21-21343342-21343409,
chr21-21350227-21350448,
chr21-21350979-21351262,
chr21-21355225-21355913,
chr21-21356160-21356982,
chr21-21357570-21358689,
chr21-21364506-21364733,
chr21-21364948-21365249,
chr21-21366244-21366797,
chr21-21371512-21371716,
chr21-21372794-21375021,
chr21-21376479-21377878,
chr21-21384013-21384369,
chr21-21385085-21385469,
chr21-21385789-21386301,
chr21-21387163-21387269,
chr21-21389784-21390206,
chr21-21390561-21390746,
chr21-21393382-21393921,
chr21-21396373-21396843,
chr21-21397231-21397918,
chr21-21401407-21402637,
chr21-21403870-21404755,
chr21-21407691-21407878,
chr21-21408906-21409176,
chr21-21409841-21410665,
chr21-21414573-21414828,
chr21-21415329-21415679,
chr21-21420899-21421292,
chr21-21422930-21423084,
chr21-21430784-21431025,
chr21-21436028-21436644,
chr21-21441589-21442112,
chr21-21442729-21442894,
chr21-21449499-21449694,
chr21-21449972-21450285,
chr21-21450772-21450888,
chr21-21452328-21453214,
chr21-21453551-21453982,
chr21-21454790-21455712,
chr21-21458100-21458506,
chr21-21459856-21460071,
chr21-21461551-21461728,
chr21-21464648-21465086,
chr21-21472922-21473063,
chr21-21474965-21475125,
chr21-21479064-21479763,
chr21-21480079-21480400,
chr21-21482448-21483177,
chr21-21486033-21486320,
chr21-21486774-21487412,
chr21-21488735-21489303,
chr21-21498603-21498873,
chr21-21499244-21499516,
chr21-21499847-21500164,
chr21-21503834-21504094,
chr21-21504576-21504817,
chr21-21507264-21507759,
chr21-21508592-21508813,
chr21-21509024-21509582,
chr21-21513839-21514244,
chr21-21514621-21514951,
chr21-21519607-21519934,
chr21-21530827-21531064,
chr21-21536415-21536718,
chr21-21541326-21541511,
chr21-21541743-21542453,
chr21-21547562-21547890,
chr21-21612405-21613123,
chr21-21616566-21616922,
chr21-21622247-21622477,
chr21-21624671-21625381,
chr21-21652570-21652878,
chr21-21664480-21665250,
chr21-21672000-21672173,
chr21-21672723-21673384,
chr21-21674080-21674302,
chr21-21677463-21677700,
chr21-21681904-21684103,
chr21-21684367-21684572,
chr21-21688058-21690974,
chr21-21694211-21694449,
chr21-21695412-21695709,
chr21-21696316-21696586,
chr21-21696845-21697203,
chr21-21704296-21705266,
chr21-21711068-21711334,
chr21-21711978-21716623,
chr21-21717255-21717986,
chr21-21718253-21718657,
chr21-21722433-21723088,
chr21-21749555-21750913,
chr21-21751266-21751708,
chr21-21762626-21762693,
chr21-21765561-21766144,
chr21-21770935-21771508,
chr21-21899875-21900131,
chr21-21902184-21902983,
chr21-21903304-21903667,
chr21-21907619-21907903,
chr21-21912459-21912598,
chr21-21920462-21922852,
chr21-21940756-21941216,
chr21-21942118-21942417,
chr21-21943970-21944186,
chr21-22110969-22111267,
chr21-22120614-22121391,
chr21-22123357-22123566,
chr21-22535178-22537033,
chr21-22540189-22540411,
chr21-22544804-22545073,
chr21-22727369-22727621,
chr21-22728222-22728472,
chr21-22730060-22730288,
chr21-22733978-22734578,
chr21-22736136-22736373,
chr21-22742797-22743736,
chr21-22780570-22780976,
chr21-22783825-22784383,
chr21-22788643-22789360,
chr21-22789800-22793340,
chr21-22794796-22794870,
chr21-22795870-22796576,
chr21-22799147-22800143,
chr21-22884517-22885537,
chr21-22891231-22893226,
chr21-22899910-22901504,
chr21-23152070-23152626,
chr21-23160688-23161440,
chr21-23162547-23162838,
chr21-23172545-23172782,
chr21-23173553-23174100,
chr21-23378651-23378923,
chr21-23384688-23385090,
chr21-23387115-23387465,
chr21-23394155-23394961,
chr21-23400845-23402059,
chr21-23402490-23404003,
chr21-23420792-23421097,
chr21-23424206-23424485,
-
Co-expression with cohesin genes Rho = 0.2946
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.656
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.945
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: H9-endodermal,IMR-90,MCF-10A,MB157,Keratinocytes192627,H1-Mesenchymal,H1-Mesendoderm,Olfactory,Hepatocyte-H9,MCF-7,GM12891,GM12878,MSiPS,K-562,Naive-hESC,CyT49-pancreatic,HFFc6,HeLa-S3,LNCaP,SU-DHL-2,H9-hESC,KU-19-19,iPSC,REC-1,Hep-G2,HT-1197,H1-hESC,HCC1599,GM19238,HT-1376,Motor-Neuron,MSLCL,HUES64,SU-DHL-4,CyT49-hESC,HL-60,NPC-H9,CyT49-endoderm,RT-112,Skin-Fibroblast,CyT49-Gut,HFF-hTERT,HAP1
- Related loop:
chr21:18275000-18300000~~chr21:21200000-21225000,
chr21:18500000-18525000~~chr21:20975000-21000000,
chr21:20425000-20450000~~chr21:20975000-21000000,
chr21:20825000-20850000~~chr21:20975000-21000000,
chr21:20975000-21000000~~chr21:22100000-22125000,
chr21:20997997-21000834~~chr21:21101368-21102780,
chr21:20997997-21000834~~chr21:21921038-21922969,
chr21:20998668-21000692~~chr21:21101352-21103020,
chr21:20998668-21000692~~chr21:21687936-21689865,
chr21:20998668-21000692~~chr21:21920963-21923078,
chr21:20998691-21000777~~chr21:21920863-21923107,
chr21:20998732-21000680~~chr21:21688116-21689848,
chr21:20998885-21000797~~chr21:21920936-21923160,
chr21:20998901-21000721~~chr21:21688167-21689840,
chr21:20998915-21000754~~chr21:21688092-21689865,
chr21:20998922-21001330~~chr21:21372954-21374952,
chr21:20998922-21001330~~chr21:21687914-21690146,
chr21:20998922-21001330~~chr21:21920932-21923125,
chr21:20998952-21000882~~chr21:21687901-21690144,
chr21:20998995-21000797~~chr21:21688096-21689849,
chr21:20999019-21000705~~chr21:21101429-21102752,
chr21:20999019-21000705~~chr21:21688236-21689710,
chr21:20999019-21000835~~chr21:21688505-21689670,
chr21:20999033-21000971~~chr21:21921005-21922555,
chr21:20999047-21000467~~chr21:21101340-21102966,
chr21:20999048-21000699~~chr21:21101364-21102683,
chr21:20999048-21000699~~chr21:21920950-21923088,
chr21:20999061-21000675~~chr21:21101139-21102794,
chr21:20999120-21000650~~chr21:21688176-21689721,
chr21:20999150-21000700~~chr21:21921001-21922912,
chr21:21000000-21025000~~chr21:21100000-21125000,
chr21:21000000-21025000~~chr21:21150000-21175000,
chr21:21000000-21025000~~chr21:21200000-21225000,
chr21:21000000-21025000~~chr21:21275000-21300000,
chr21:21000000-21025000~~chr21:21300000-21325000,
chr21:21000000-21025000~~chr21:21325000-21350000,
chr21:21000000-21025000~~chr21:21350000-21375000,
chr21:21000000-21025000~~chr21:21375000-21400000,
chr21:21000000-21025000~~chr21:21650000-21675000,
chr21:21000000-21025000~~chr21:21675000-21700000,
chr21:21000000-21025000~~chr21:21750000-21775000,
chr21:21000000-21025000~~chr21:21900000-21925000,
chr21:21000000-21025000~~chr21:21925000-21950000,
chr21:21000000-21025000~~chr21:22100000-22125000,
chr21:21000000-21025000~~chr21:22775000-22800000,
chr21:21000000-21025000~~chr21:23150000-23175000,
chr21:21000000-21025000~~chr21:23375000-23400000,
chr21:21000000-21025000~~chr21:23400000-23425000,
chr21:21000000-21025000~~chr21:23675000-23700000,
chr21:21000000-21025000~~chr21:23950000-23975000,
chr21:21000000-21025000~~chr21:24500000-24525000,
chr21:21000000-21025000~~chr21:24875000-24900000,
chr21:21000000-21025000~~chr21:25000000-25025000,
chr21:21000000-21025000~~chr21:25025000-25050000,
chr21:21000000-21025000~~chr21:25300000-25325000,
chr21:21000000-21025000~~chr21:25325000-25350000,
chr21:21000000-21025000~~chr21:25375000-25400000,
chr21:21003038-21004640~~chr21:21101289-21102786,
chr21:21003051-21004829~~chr21:21101340-21102914,
chr21:21003058-21004646~~chr21:21688144-21689874,
chr21:21003058-21004646~~chr21:21920972-21923111,
chr21:21003089-21004639~~chr21:21101203-21103013,
chr21:21003101-21004721~~chr21:21101174-21102946,
chr21:21003101-21004721~~chr21:21688167-21689840,
chr21:21003101-21004721~~chr21:21920938-21922813,
chr21:21003128-21004732~~chr21:21372936-21375055,
chr21:21003137-21004624~~chr21:21688096-21689849,
chr21:21003151-21004646~~chr21:21372959-21374950,
chr21:21003151-21004646~~chr21:21687901-21690144,
chr21:21003151-21004646~~chr21:21920910-21923131,
chr21:21003163-21004635~~chr21:21687914-21690146,
chr21:21003242-21004641~~chr21:21101303-21102752,
chr21:21003264-21004580~~chr21:21687914-21690120,
chr21:21003266-21004597~~chr21:21101164-21102785,
chr21:21003271-21004562~~chr21:21101398-21102732,
chr21:21003276-21004585~~chr21:21101357-21102787,
chr21:21003301-21004546~~chr21:21921038-21922969,
chr21:21050000-21075000~~chr21:22725000-22750000,
chr21:21150000-21175000~~chr21:21300000-21325000,
chr21:21150000-21175000~~chr21:21350000-21375000,
chr21:21150000-21175000~~chr21:21675000-21700000,
chr21:21150000-21175000~~chr21:21900000-21925000,
chr21:21150000-21175000~~chr21:21925000-21950000,
chr21:21150000-21175000~~chr21:22775000-22800000,
chr21:21150000-21175000~~chr21:25375000-25400000,
chr21:21162538-21166096~~chr21:21372954-21374952,
chr21:21162538-21166096~~chr21:21920932-21923125,
chr21:21162657-21165063~~chr21:21687931-21690091,
chr21:21163026-21165402~~chr21:21920972-21923111,
chr21:21163031-21165075~~chr21:21920929-21923014,
chr21:21163052-21166114~~chr21:21372959-21374950,
chr21:21163052-21166114~~chr21:21687901-21690144,
chr21:21163062-21164785~~chr21:21921001-21922912,
chr21:21163064-21165959~~chr21:21688044-21689859,
chr21:21163079-21165031~~chr21:21687926-21689834,
chr21:21163085-21165071~~chr21:21688096-21689849,
chr21:21163085-21165071~~chr21:21920925-21923025,
chr21:21163114-21165063~~chr21:21687936-21689865,
chr21:21163114-21165063~~chr21:21920963-21923078,
chr21:21163194-21164851~~chr21:21921005-21922555,
chr21:21163211-21164788~~chr21:21688204-21689703,
chr21:21163279-21165047~~chr21:21687914-21690120,
chr21:21163279-21165047~~chr21:21920950-21923088,
chr21:21163351-21164698~~chr21:21688111-21689755,
chr21:21163353-21164783~~chr21:21920979-21922536,
chr21:21175000-21200000~~chr21:21600000-21625000,
chr21:21175000-21200000~~chr21:21675000-21700000,
chr21:21175000-21200000~~chr21:21700000-21725000,
chr21:21175000-21200000~~chr21:21900000-21925000,
chr21:21175000-21200000~~chr21:25325000-25350000,
chr21:21175000-21200000~~chr21:25350000-25375000,
chr21:21200000-21225000~~chr21:21900000-21925000,
chr21:21225000-21250000~~chr21:21350000-21375000,
chr21:21225000-21250000~~chr21:21450000-21475000,
chr21:21225000-21250000~~chr21:21475000-21500000,
chr21:21225000-21250000~~chr21:21500000-21525000,
chr21:21225000-21250000~~chr21:21600000-21625000,
chr21:21225000-21250000~~chr21:21675000-21700000,
chr21:21225000-21250000~~chr21:21900000-21925000,
chr21:21225000-21250000~~chr21:22100000-22125000,
chr21:21225000-21250000~~chr21:22525000-22550000,
chr21:21225000-21250000~~chr21:22775000-22800000,
chr21:21225000-21250000~~chr21:22875000-22900000,
chr21:21225000-21250000~~chr21:23375000-23400000,
chr21:21231430-21233404~~chr21:21920936-21923160,
chr21:21231477-21233381~~chr21:21687907-21690091,
chr21:21231521-21233402~~chr21:21687901-21690144,
chr21:21231528-21233140~~chr21:21688144-21689874,
chr21:21231535-21233401~~chr21:21687936-21689865,
chr21:21231535-21233401~~chr21:21920963-21923078,
chr21:21231535-21233410~~chr21:21920932-21923125,
chr21:21231541-21233362~~chr21:21920929-21923014,
chr21:21231560-21233379~~chr21:21687926-21689834,
chr21:21231560-21233379~~chr21:21920967-21923026,
chr21:21231567-21233381~~chr21:21921006-21922867,
chr21:21231594-21233378~~chr21:21688096-21689849,
chr21:21231694-21233389~~chr21:21687914-21690120,
chr21:21231694-21233389~~chr21:21920950-21923088,
chr21:21231825-21233156~~chr21:21921005-21922555,
chr21:21231867-21233358~~chr21:21688020-21689825,
chr21:21231867-21233358~~chr21:21921063-21923124,
chr21:21231916-21233147~~chr21:21688044-21689859,
chr21:21250000-21275000~~chr21:21650000-21675000,
chr21:21350000-21375000~~chr21:21600000-21625000,
chr21:21350000-21375000~~chr21:21675000-21700000,
chr21:21350000-21375000~~chr21:21900000-21925000,
chr21:21350000-21375000~~chr21:22775000-22800000,
chr21:21373026-21375271~~chr21:21920936-21923160,
chr21:21375000-21400000~~chr21:21900000-21925000,
chr21:21375000-21400000~~chr21:22775000-22800000,
chr21:21450000-21475000~~chr21:21900000-21925000,
chr21:21450000-21475000~~chr21:22775000-22800000,
chr21:21475000-21500000~~chr21:21900000-21925000,
chr21:21475000-21500000~~chr21:22775000-22800000,
chr21:21500000-21525000~~chr21:21600000-21625000,
chr21:21500000-21525000~~chr21:21675000-21700000,
chr21:21500000-21525000~~chr21:21900000-21925000,
chr21:21500000-21525000~~chr21:22775000-22800000,
chr21:21500000-21525000~~chr21:22875000-22900000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIQYQWPF5, GSE95015, GSE43070, 4DNFIDJ2JZ7Q, 4DNFITUOMFUQ, ENCSR794RDS, ENCSR852KQC, 4DNFIZ4F74QR, 4DNFI7H4II2V, 4DNFIEYQ5ZIR, 4DNFIREVU1Z5, 4DNFIA6NSSBJ, ENCSR113OIR, 4DNFIKYXMF1E, GSE99541, GSE97394, 4DNFICEGAHRC, 4DNFIE8T8JZ8, 4DNFI9YAVTI1, ENCSR658RQQ, ENCSR299VMZ, 4DNFISPUVQHA, 4DNFI8Y9SRP2, 4DNFIK61ILGM, GSE116872, ENCSR527RXH, GSE105028, 4DNFIQWD8ZYD, ENCSR478BMT, GSE69643, GSE155380, 4DNFIJWBWE41, 4DNFICSTCJQZ, ENCSR587DSF, ENCSR452NHL, 4DNFIIMZB6Y9, GSE52457, Direct, 4DNFIX7H3CE2, 4DNFI9815EEJ, ENCSR778FXH, 4DNFI9ZWZ5BS, 4DNFI2J1ODWB, 4DNFIVJ3IIQL, 4DNFIQ2687RT, 4DNFIFLJLIS5, 4DNFIDZT7PR8, 4DNFIH7TH4MF, 4DNFIWZEN3FF, ENCSR194SRI, 4DNFIR8OU6QJ, 4DNFIE8E4ANZ, GSE120294, 4DNFIW8TIFI5, ENCSR410MDC, ENCSR732QOH, 4DNFIBM714BP, 4DNFIYD8LO9Z, 4DNFIL9M97T2, 4DNFI3A3VYWU, 4DNFIYDBBSE3, ENCSR386KHY, 4DNFIEJEFCAM, ENCSR404HWQ, 4DNFIJ8JKKWJ, 4DNFIFI6NIKJ, ENCSR933UZH, ENCSR094EIC, GSE116869, 4DNFI8649RQJ, GSE116875, 4DNFIMROE6N4, GSE108787, 4DNFI5SUHCGZ, ENCSR545YBD, 4DNFI6EIFUZI, 4DNFII6AN691, GSE131580, ENCSR381DCY, ENCSR128RPG, 4DNFI6JJQKFJ, 4DNFI1UEG1HD, GSE101921, 4DNFIC3HAU11, 4DNFIQVMVRP6, ENCSR247RGI, ENCSR338WUS, 4DNFI5LCW273, 4DNFINEQY95T, 4DNFII84FBKM, 4DNFIVSCH2CH
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: SLK,P3HR-1,K-562,MCF-10A,CMK,HAP1,U2OS,Kasumi-1
- Cohesin-DEGs, number of studies: 11
- Cohesin-DEGs, study: GSE140651,GSE101921,GSE154086,GSE126635,GSE131448,GSE138937,GSE89799,GSE47641
- Cohesin-DEGs, subunit: CTCF,Rad21,SA2,SMC1