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Basic information

CohesinDB ID: CDBP00413534

Locus: chr21-15603827-15604974

Data sourse: ENCSR000BTU, ENCSR853VWZ, GSE72082, ENCSR193NSH, GSE138405, GSE116344, GSE25021, GSE206145, GSE101921, GSE85526, GSE206145-NatGen2015, ENCSR000EDE, GSE68388, ENCSR703TNG, GSE126990, GSE108869, ENCSR000ECS, ENCSR217ELF

Cell type: MCF-7, RPE, HMEC, Fibroblast, Hela-Kyoto, RH4, HEKn, Ishikawa, A-549, HeLa-S3, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 7% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 56% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 76%, "7_Enh": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, ZNF660, SOX2, FOXA1, ZFHX2, TFAP4, ATF3, NFIC, PRDM1, SMARCE1, KLF5, TEAD1, KLF6, ZNF217, ESR1, USF2, CTCF, TCF12, JUN, EP300, KLF1, DPF2, RFX5, DEK, E2F4, SMC1, TEAD4, GTF2F1, TFAP2C, NANOG, POU5F1, CTBP1, STAT1, SRF, GATAD1, TBP, ERG, HOXC5, MYC, SMARCA4, RAD21, LHX2, PROX1, NKX2-1, GABPA, STAT3, RCOR1, ZNF750, CEBPB, NR3C1, CREB1, GRHL2, EHF, HDAC2, GATA2, FLI1, MXI1, MRTFB, MYF5, CBX1, SMC1A, EZH2phosphoT487, SIN3A, AFF4, SMAD3, ERG3, SMARCC1, TWIST1, ZXDC, CREBBP, PBX4, NFIB, FOXM1, FOS, CHD1, MED1, KLF9, TBX5, MAFK, ZHX1, ASH2L, SMC3, ELL2, NCOR2, STAG1, FOXA2, CHD2, ZNF692, GTF2B, MAFF, HOXB13, KDM1A, YY1, RELA, JUNB, HIF1A, OTX2, GATA3, MAX, NRIP1, HAND2, KLF4, TP53, PKNOX1, EGR2, PHOX2B, ELF3, BRD2, AR, PAX3-FOXO1, YAP1, BRD4, JUND, CUX1, BRCA1, AHR

Target gene symbol (double-evidenced CRMs): BTG3,USP25

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000155313, ENSG00000154640,

eachgene

Deatailed information for cohesin site CDBP00413534