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Basic information

CohesinDB ID: CDBP00413571

Locus: chr21-15728664-15733925

Data sourse: ENCSR230ZWH, ENCSR000BSB, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE111537, GSE25021, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 66% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.256

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 56% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "1_TssA": 25%, "2_TssAFlnk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, SFPQ, TEAD1, LMO2, OCA2, MED26, PITX3, ZNF561, ARID5B, E4F1, SOX5, PAX8, E2F4, DEK, ZNF410, RFX3, KLF3, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, TOP2A, ZNF263, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, FOXK2, UBN1, RCOR1, NR2F6, NFRKB, CD74, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, ELF4, MIXL1, ZNF257, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, NR2C2, DRAP1, MXI1, RELB, HCFC1R1, EP400, RUVBL2, RUNX1, CEBPA, HDAC1, NKX2-2, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ELK1, SOX11, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, C11orf30, EVI1, GSPT2, IKZF5, ARID2, AFF1, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, NFATC1, PAF1, SS18, ZSCAN16, ZNF17, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, IRF5, MED, BCL6B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, HNRNPK, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, ZNF467, MAF, INTS11, ELF1, ZNF573, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, TAF3, CTCF, MNT, ZBTB20, LMO1, RYBP, DPF2, IRF4, DDX20, ZNF677, ZNF350, PDX1, RBPJ, TFAP2C, MLX, YBX1, MTA2, ZBTB17, ZBTB48, ZNF317, NONO, SRF, DDX5, NBN, ZNF626, ONECUT1, KDM4A, HOMEZ, FOXP2, ZKSCAN2, TSHZ1, RXRA, NKX3-1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, TBL1XR1, KLF8, GRHL2, EBF3, ZBTB14, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, ZNF585A, EZH2phosphoT487, SOX13, AFF4, ZMIZ1, ZNF18, SP3, DAXX, BACH1, ARNT, ZNF48, ZEB2, HMBOX1, ETV6, NCAPH2, ZNF10, PBX3, HMGXB4, TEAD3, ZNF680, U2AF1, TAF7, KLF9, TBX5, USF1, SP1, TFAP2A, BCL11A, ATF7, ASH2L, PCGF2, CTBP2, GLIS2, PRDM6, SMC3, STAT2, STAG1, STAG2, MLLT1, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ZNF580, ZKSCAN1, KDM1A, BRG1, ISL1, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, SPIN1, ZSCAN23, TBX2, ZNF468, PGR, FANCL, SOX2, PATZ1, RING1B, UBTF, LEO1, TFAP4, SIN3B, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, TP73, KLF1, ZNF695, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, HIC1, SP4, ERG2, TBP, HOXC5, SMARCC2, ETS1, MYC, ARID1B, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, INO80, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, INTS13, ZNF182, GATAD2B, ZNF76, NCOA2, ETV5, BCL6, SIN3A, ZFP37, ERG3, NFXL1, RARA, ZNF35, CREBBP, NFYC, TAF15, ZNF384, SMAD4, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, SREBF2, ZNF22, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, HOXA9, BCOR, FOXP1, AATF, NCOR2, ZNF34, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, TCF7, YY2, FOXO3, ZNF318, RELA, TARDBP, CHAMP1, SKIL, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, ZNF547, RUVBL1, AR, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, E2F7, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, NFIC, ZNF362, CTCFL, PRDM1, MECOM, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, ZNF557, RCOR2, HNF1B, MLL, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, ARID3A, ZNF300, MIER1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, JMJD6, FEZF1, TRPS1, HBP1, TFE3, EHF, IRF1, ZNF664, ZGPAT, NAB2, ZNF766, MRTFB, ATF1, PTBP1, MAFG, CBX1, SMC1A, SIRT6, ZNF335, ZNF534, ZFX, FIP1L1, SMAD3, PCBP2, NMYC, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, ZSCAN30, ZNF184, OSR2, SMAD2, NRF1, PBX4, NR2C1, FOS, SUPT5H, CHD1, MED1, CEBPD, MYB, SCRT2, KDM6B, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, ZNF783, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF519, ZNF740, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF843, NFKBIZ, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): HSPA13,NRIP1,BTG3,USP25

Function elements

Human SNPs: .

Number of somatic mutations (coding): 84

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000155304, ENSG00000180530, ENSG00000155313, ENSG00000154640,

eachgene

Deatailed information for cohesin site CDBP00413571