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Basic information

CohesinDB ID: CDBP00413575

Locus: chr21-15748731-15750124

Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE138405, ENCSR000BLS, GSE206145, GSE62063, GSE126990, ENCSR917QNE

Cell type: MCF-7, RPE, Hela-Kyoto, Hep-G2, Liver, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: NIPBL,Mau2,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 57% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 50%, "7_Enh": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, PGR, SMARCA2, HMG20A, ZNF660, MEIS2, NME2, FOXA1, RXRB, PBX2, HDGF, ATF3, NFIC, ZNF362, SMARCE1, ZNF287, BACH2, TEAD1, TRIM28, SNAI2, NFE2L2, ESR1, HNF1B, JUN, TCF12, CTCF, BAF155, E4F1, EP300, MNT, GATA6, SOX5, DPF2, TRIM24, SOX6, TEAD4, FOXA3, GATAD2A, PDX1, NANOG, POU5F1, TOP2A, MTA2, ZBTB48, SAP130, NBN, ARID3A, DDX5, HNF4G, ERG, MIER1, SMARCC2, MYC, ONECUT1, SMARCA4, ARID1B, RAD21, HOMEZ, GRHL3, RXRA, NKX2-1, FOXK2, GABPA, NKX3-1, IKZF1, MIER3, NFE2, ZNF639, NFRKB, LEF1, RCOR1, DACH1, CEBPB, CREB1, TBL1XR1, FEZF1, NFE2L1, SPI1, MIXL1, IRF1, HDAC2, GATA2, GATAD2B, ZGPAT, SMARCA5, NFIL3, MRTFB, EP400, NCOA2, RUNX1, THAP11, BCL6, MAFG, CEBPA, NKX2-2, HDAC1, SMC1A, SOX13, LDB1, ZFX, ZNF770, ERG3, ZMIZ1, MYBL2, ZBTB2, ZNF384, RUNX2, CDK6, GATA4, NRF1, PBX4, BACH1, ARNT, ZEB2, NFYA, HMBOX1, CBFA2T3, MAFB, NR2C1, FOXM1, FOS, SMARCB1, SMAD4, GMEB1, TEAD3, PML, CEBPD, ZMYM3, PIAS1, C11orf30, STAT5A, RBM22, MAFK, SP1, BCL11A, NR4A1, HNF4A, REST, ARID1A, ZBTB7A, CCNT2, ASH2L, PHIP, FOXP1, PRDM6, MLLT1, NFATC3, ZNF283, CBFA2T2, FOXA2, CBX3, CREM, MTA3, PAF1, ZSCAN16, MAFF, WT1, ZBTB33, HOXB13, ZNF318, KDM1A, YY1, RELA, JUNB, NEUROD1, CHAMP1, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, TLE3, CEBPG, ZNF592, SP7, GFI1B, NR2F2, NR2F1, PKNOX1, PHOX2B, AR, ZBTB40, ZBTB42, RNF2, NCOR1, SCRT1, BRD4, ILF3, CLOCK, JUND, ZNF316

Target gene symbol (double-evidenced CRMs): USP25,BTG3,NRIP1,HSPA13

Function elements

Human SNPs: .

Number of somatic mutations (coding): 48

Number of somatic mutations (non-coding): 12

Related genes and loops

Related gene: ENSG00000155304, ENSG00000180530, ENSG00000155313, ENSG00000154640,

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Deatailed information for cohesin site CDBP00413575