- Basic information
- CohesinDB ID: CDBP00413789
- Locus: chr21-16569553-16572421
-
Data sourse: GSE138405, ENCSR000BLY, GSE206145, ENCSR000EDE, GSE126990, GSE108869, ENCSR000ECS, GSE165895
-
Cell type: RPE, Hela-Kyoto, HeLa-S3, SK-N-SH, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
40% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 46%,
"7_Enh": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, FOSL1, ZNF660, SOX2, FOXA1, CHD7, TEAD1, ETV1, NFE2L2, CTCF, JUN, TCF12, EP300, E2F1, TEAD4, RBPJ, CHD8, BRD3, TOP2A, ZBTB48, HIC1, ERG, HOXC5, SMARCA4, RAD21, GRHL3, GABPA, STAT3, UBN1, NFE2, VDR, NR3C1, CEBPB, KMT2A, CREB1, EBF3, GATA2, FLI1, ZIM3, SMC1A, AFF4, ZFX, SMAD3, SMARCC1, ZNF384, RUNX2, GATA4, PBX4, NRF1, ARNT, ATF2, PBX3, FOS, MED1, CEBPD, ZNF680, SUPT16H, MAFK, BCL11A, NIPBL, ZBTB7A, ATF7, ZHX1, PRDM6, SMC3, FOXA2, GTF2B, MAFF, FOXF1, HOXB13, RELA, JUNB, ISL1, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, HAND2, TP53, BRD2, AR, YAP1, EGLN2, ZNF366, BRD4, JUND, BRCA1, FOSL2
- Target gene symbol (double-evidenced CRMs): BTG3,NRIP1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 30
- Related genes and loops
- Related gene:
ENSG00000180530,
ENSG00000154640,
- Related loop:
chr21:14975000-15000000~~chr21:16550000-16575000,
chr21:15000000-15025000~~chr21:16550000-16575000,
chr21:16050000-16075000~~chr21:16575000-16600000,
chr21:16075000-16100000~~chr21:16550000-16575000,
chr21:16075000-16100000~~chr21:16575000-16600000,
chr21:16175000-16200000~~chr21:16550000-16575000,
chr21:16175000-16200000~~chr21:16575000-16600000,
chr21:16325000-16350000~~chr21:16575000-16600000,
chr21:16400000-16425000~~chr21:16575000-16600000,
chr21:16450000-16475000~~chr21:16550000-16575000,
chr21:16450000-16475000~~chr21:16575000-16600000,
chr21:16453763-16456291~~chr21:16572937-16574492,
chr21:16550000-16575000~~chr21:17450000-17475000,
chr21:16550000-16575000~~chr21:17600000-17625000,
chr21:16575000-16600000~~chr21:16825000-16850000,
chr21:16575000-16600000~~chr21:16850000-16875000,
chr21:16575000-16600000~~chr21:17800000-17825000,