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Basic information

CohesinDB ID: CDBP00413790

Locus: chr21-16572677-16573040

Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783

Cell type: RPE, Fibroblast, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 40% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 69%, "5_TxWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, ZNF660, SOX2, FOXA1, CHD7, TEAD1, ETV1, NFE2L2, CTCF, JUN, TCF12, EP300, E2F1, TEAD4, RBPJ, CHD8, BRD3, TOP2A, ZBTB48, HIC1, ERG, HOXC5, SMARCA4, RAD21, GRHL3, GABPA, STAT3, UBN1, NFE2, VDR, NR3C1, CEBPB, KMT2A, CREB1, EBF3, GATA2, FLI1, ZIM3, SMC1A, AFF4, ZFX, SMAD3, SMARCC1, ZNF384, RUNX2, GATA4, PBX4, NRF1, ARNT, ATF2, PBX3, FOS, MED1, CEBPD, ZNF680, SUPT16H, MAFK, BCL11A, NIPBL, ZBTB7A, ATF7, ZHX1, PRDM6, SMC3, FOXA2, GTF2B, MAFF, FOXF1, HOXB13, RELA, JUNB, ISL1, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, HAND2, TP53, BRD2, AR, YAP1, EGLN2, ZNF366, BRD4, JUND, BRCA1, FOSL2

Target gene symbol (double-evidenced CRMs): BTG3,NRIP1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000180530, ENSG00000154640,

eachgene

Deatailed information for cohesin site CDBP00413790