- Basic information
- CohesinDB ID: CDBP00413921
- Locus: chr21-17371078-17371857
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Data sourse: ENCSR000BLD, ENCSR000BTU, GSE138405, GSE101921, GSE85526, GSE138105, GSE126990
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Cell type: H1-hESC, HMEC, Hela-Kyoto, MCF-10A, HEKn, SLK, Ishikawa, HCAEC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: Rad21,SA2,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
46% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 64%,
"7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, SMARCA2, SOX2, FOXA1, NFIC, CHD7, PRDM1, DPF1, TEAD1, ETV1, SNAI2, ZNF217, ESR1, USF2, CTCF, JUN, TCF12, BAF155, EP300, E2F6, TEAD4, FOXA3, PDX1, RBPJ, NANOG, MYCN, SRF, ERG, PAX6, ASCL1, ONECUT1, RAD21, LHX2, NKX2-1, STAT3, XRCC5, NKX3-1, RCOR1, VDR, ZNF750, ESRRA, NR3C1, CREB1, GRHL2, GATA2, SIX2, FLI1, ZGPAT, MRTFB, RUNX1, CBX1, ZBTB24, SMC1A, SIN3A, ZFX, SMAD3, CREBBP, ZNF384, NOTCH1, PBX4, ARNT, SOX11, PRDM9, PBX3, FOS, MED1, ZEB1, TEAD3, PIAS1, USF1, ARID1A, ASH2L, CTBP2, FOXP1, STAG2, STAG1, FOXA2, WT1, HOXB13, KDM1A, YY1, RELA, JUNB, BRG1, HIF1A, OTX2, GATA3, TAL1, MAX, TLE3, KLF4, KDM5B, TP53, PKNOX1, NFKB1, ELF3, BRD2, AR, TAF1, EGLN2, BRD4, JUND, FOSL2
- Target gene symbol (double-evidenced CRMs): C21orf91,TMPRSS15
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000154642,
ENSG00000154646,
- Related loop:
chr21:16925000-16950000~~chr21:17350000-17375000,
chr21:16925000-16950000~~chr21:17375000-17400000,
chr21:17100000-17125000~~chr21:17350000-17375000,
chr21:17125000-17150000~~chr21:17350000-17375000,
chr21:17350000-17375000~~chr21:17775000-17800000,
chr21:17350000-17375000~~chr21:17900000-17925000,
chr21:17350000-17375000~~chr21:18250000-18275000,
chr21:17351425-17352731~~chr21:17369915-17372377,
chr21:17375000-17400000~~chr21:17500000-17525000,
chr21:17375000-17400000~~chr21:17550000-17575000,
chr21:17375000-17400000~~chr21:17575000-17600000,
chr21:17375000-17400000~~chr21:17775000-17800000,
chr21:17375000-17400000~~chr21:17825000-17850000,