- Basic information
- CohesinDB ID: CDBP00413979
- Locus: chr21-17527049-17527805
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Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR150EFU, ENCSR000ECS, GSE108869, GSE138405, GSE76893, GSE101921, ENCSR895JMI, ENCSR193NSH, ENCSR768DOX, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR620NWG, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, GSE68388, GSE126990, ENCSR748MVX
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Cell type: MCF-7, RPE, Hela-Kyoto, Hep-G2, A-549, HCAEC, HeLa-S3, Liver, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 10% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
60% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 38%,
"7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, PGR, HMG20A, LCORL, ZNF660, SOX2, HNF1A, FOXA1, HLF, RBFOX2, RXRB, MLL4, KDM3A, TFAP4, TSC22D4, THRB, ATF3, NFIC, ZFP64, ZNF362, CHD7, PRDM1, ZBTB44, MXD4, ZNF189, SMARCE1, ZSCAN4, MZF1, CDX2, ZNF467, TEAD1, TRIM28, ELF1, KLF6, ETV1, ZNF121, KLF10, RCOR2, ESR1, OCA2, LMO2, HNF1B, ZNF217, USF2, MBD4, CTCF, TCF12, JUN, EP300, BAF155, L3MBTL4, MNT, SOX9, SOX5, GATA6, DPF2, PRDM4, RFX5, RFX3, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, MLX, TFAP2C, NANOG, CHD8, ZNF425, ZNF263, HHEX, CTBP1, ZNF317, ZBTB48, DUX4, SRF, GATAD1, SAP130, DDX5, HIC1, ARID3A, GMEB2, TBP, HNF4G, ERG, ETS1, MYC, RFX1, HOMEZ, RAD21, ARID1B, GRHL3, LHX2, FOXP2, PROX1, RXRA, FOXK2, NKX2-1, GABPA, STAT3, ZNF614, XRCC5, NKX3-1, MIER3, DNMT3B, NR2F6, TCF25, RCOR1, NR3C1, ESRRA, CEBPB, ZNF750, CREB1, TBL1XR1, EZH2, GRHL2, FEZF1, ZNF652, EBF3, TRPS1, GABPB1, ZHX2, MIXL1, TFE3, HBP1, ZSCAN2, ZNF664, IRF1, HDAC2, GATA2, SSRP1, ZNF644, GATAD2B, FLI1, DRAP1, ZGPAT, NR2C2, MXI1, ATM, MRTFB, NFIL3, NCOA2, ETV5, RUNX1, THAP11, CTNNB1, BCL6, SMC1A, CEBPA, CBX1, NKX2-2, SOX13, AFF4, SIN3A, ZNF534, ZFX, SMAD3, TBX3, ERG3, SP5, SMARCC1, PRDM10, MYBL2, RARA, CREBBP, NFYC, ZNF35, ZNF384, RUNX2, ZSCAN30, GATA4, OSR2, GR, PBX4, ARNT, NRF1, ATF2, ZNF48, SMAD4, FOXM1, MAFB, ZNF10, SMARCB1, HMGXB4, FOS, TGIF2, CDK8, MED1, PBX3, TEAD3, ZEB1, CEBPD, MYB, SCRT2, PIAS1, ZMYM3, SPDEF, ZNF3, NR1H2, TBX5, MBD1, RBM22, MAFK, NIPBL, TFAP2A, SP1, HNF4A, BCL11A, IKZF5, REST, ARID2, ATF7, ZHX1, ASH2L, POU2F3, HOXA9, PHIP, FOXP1, PRDM6, SMC3, ELL2, ZNF34, STAG1, STAG2, ETV4, ZNF394, SKI, ZNF283, PPARG, FOXA2, CREM, EBF1, PAF1, CHD2, MIER2, ZSCAN16, GTF2B, MAFF, ZNF692, FOXF1, ZBTB33, TCF7, HOXB13, ZNF580, ZKSCAN1, KDM1A, YY1, RELA, FOXO3, BCL3, JUNB, AHR, MCM3, BRCA1, HIF1A, OTX2, GATA3, TAL1, MAX, MAF1, NRIP1, ZNF143, AGO2, GATA1, TLE3, CEBPG, KLF4, SP7, NCOA3, NR2F2, NR2F1, TCF7L2, TP53, RUVBL1, ZNF334, NFKB1, EGR2, PHOX2B, BRD2, ELF3, KAT8, PHF5A, ARID4B, NFKBIZ, AR, BHLHE40, TAF1, RXR, YAP1, ZNF366, ZBTB42, ZBTB26, NCOR1, RNF2, SCRT1, JUND, BRD4, HSF1, CUX1, MAZ, SMAD4.1D12, ZNF24, DMAP1, FOSL2
- Target gene symbol (double-evidenced CRMs): CXADR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 15
- Number of somatic mutations (non-coding): 2
- Related genes and loops