- Basic information
- CohesinDB ID: CDBP00413985
- Locus: chr21-17538838-17539668
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Data sourse: GSE103477, GSE62063, ENCSR167MTG, GSE98367
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Cell type: Macrophage, THP-1, Hep-G2, Ramos
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: NIPBL,SA1,Rad21,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
60% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 40%,
"5_TxWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, ZSCAN5C, SOX2, MEIS2, FOXA1, HLF, PBX2, RXRB, TFAP4, LYL1, BMI1, ATF3, ZBTB44, PRDM1, ZNF189, SMARCE1, PAX5, TP63, CDX2, MAF, JMJD1C, TEAD1, TRIM28, ZNF121, ETV1, ZNF217, ESR1, OCA2, TP73, MLL, USF2, JUN, TCF12, CTCF, BAF155, EP300, NUTM1, MNT, GATA6, SOX5, DPF2, PRDM4, TRIM24, RFX5, TEAD4, FOXA3, ZNF175, KMT2B, GATAD2A, GTF2F1, TFAP2C, RBPJ, NANOG, MYCN, POU5F1, TOP2A, CTBP1, ERF, ZBTB17, ZBTB48, STAT1, GATAD1, SAP130, HIC1, ARID3A, TBP, HNF4G, ERG, ETS1, MYC, HOMEZ, RAD21, LHX2, ZNF24, GRHL3, RXRA, NKX2-1, GABPA, ZNF197, STAT3, XRCC5, NKX3-1, IKZF1, RCOR1, ZNF639, NR2F6, ZNF750, ESRRA, CEBPB, NR3C1, KMT2A, CREB1, EZH2, GRHL2, FEZF1, EBF3, TRPS1, SPI1, MIXL1, IRF1, HDAC2, GATA2, ZNF644, GATAD2B, FLI1, ZGPAT, MXI1, MRTFB, NCOA2, NFIL3, RUNX1, THAP11, SMC1A, BCL6, CEBPA, EZH2phosphoT487, LDB1, SOX13, AFF4, SIN3A, ZFX, SMAD3, ZFP37, CREBBP, RARA, ZSCAN30, GATA4, OSR2, GR, PBX4, ARNT, SMAD4, CBFA2T3, PBX3, ZNF10, FOXM1, CDK8, FOS, ZEB1, TEAD3, ZNF558, MYB, SCRT2, PIAS1, SETDB1, STAT5A, RBM22, MAFK, NIPBL, TFAP2A, BCL11A, HNF4A, SP1, IKZF5, REST, ZHX1, POU2F3, CTBP2, PHIP, MBD2, FOXP1, PRDM6, SMC3, ELL2, MLLT1, ZNF394, MEF2B, PPARG, FOXA2, EBF1, CHD2, ZNF600, ZNF692, WT1, MAFF, MEF2C, TCF7, CDK9, HOXB13, KDM1A, RELA, NEUROD1, JUNB, ISL1, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, GATA1, MTA1, SPIB, AGO2, HAND2, TLE3, KLF4, BCL11B, SP7, NCOA3, CEBPG, NR2F2, TCF7L2, TP53, PKNOX1, ZNF334, PHOX2B, ELF3, ARID4B, AR, NFKBIZ, RXR, EGLN2, ZNF366, MAML3, BRD4, JUND, CLOCK, CUX1, TBX2, BRCA1, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): CXADR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 15
- Number of somatic mutations (non-coding): 0
- Related genes and loops