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Basic information

CohesinDB ID: CDBP00414041

Locus: chr21-17783465-17785440

Data sourse: GSE38395, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE98367, GSE206145, GSE62063, GSE120943, ENCSR000BMY, GSE111537, GSE50893, GSE126755

Cell type: GM2610, GM19240, B-cell, GM2630, GM12890, hLCL, Neutrophil, GM2255, GM18486, SNYDER, Monocytes, GM12878, GM12891, GM2588, GM19239, Macrophage, Ramos, GM12892, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 8% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.778

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 47% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 34%, "7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, CBX5, HMG20A, XBP1, FOXA1, HLF, RXRB, ATF3, NFIC, RUNX3, CBFB, MECOM, PAX5, TP63, BACH2, MAF, JMJD1C, INTS11, ELF1, TRIM28, BCLAF1, TEAD1, KLF6, SMAD5, ZNF217, LMO2, ESR1, TP73, RCOR2, OCA2, CTCF, TCF12, JUN, EP300, LMO1, SOX5, DPF2, SIX5, IRF4, TRIM24, KMT2B, FOXA3, GTF2F1, PDX1, RBPJ, EED, GATAD2A, TFAP2C, POU2F2, ZNF425, BRD3, POU5F1, CDK7, TOP2A, MTA2, DUX4, STAT1, ZNF134, GATAD1, SAP130, NBN, ARID3A, ERG, HOXC5, CHD4, ZNF341, NFKB2, MYC, HOMEZ, RAD21, GRHL3, NKX2-1, FOXK2, BATF3, GABPA, STAT3, ZNF614, XRCC5, IKZF1, RCOR1, NFE2, MIER3, NR2F6, VDR, NR3C1, CEBPB, KMT2A, CREB1, EZH2, FEZF1, GRHL2, SPI1, MIXL1, IRF1, HDAC2, INTS13, GATA2, ZNF644, GATAD2B, FLI1, DRAP1, ZGPAT, SMARCA5, RELB, NFIL3, NFYB, NCOA2, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, AFF4, ZFX, SOX13, SMAD3, TRIM22, MEF2A, CREBBP, ZBTB2, NOTCH1, ZNF384, RARA, ARNT, PBX4, BACH1, SOX11, ATF2, SMAD4, FOXM1, ETV6, ZNF10, SUPT5H, CDK8, PBX3, FOS, HMGXB4, MED1, TEAD3, PML, ZEB1, MYB, SCRT2, ZMYM3, SMAD1, EVI1, SETDB1, STAT5A, RBM22, MAFK, SP1, BCL11A, NIPBL, NR4A1, HNF4A, IKZF5, REST, RBM25, ATF7, POU2F3, ASH2L, BCOR, TCF3, FOXP1, NCOR2, MLLT1, NFATC3, SKI, MEF2B, PPARG, FOXA2, MTA3, CREM, EBF1, NFATC1, E2F8, HDAC6, MIER2, GTF2B, ZBED1, PAF1, MEF2C, TCF7, CDK9, ZNF580, BCL3, KDM1A, YY1, RELA, ZNF19, TARDBP, JUNB, SKIL, HIF1A, GATA3, BATF, TAL1, MAX, SPIB, ZNF143, NRIP1, CEBPG, TCF7L2, TP53, PKNOX1, ZNF334, NFKB1, PHOX2B, ELF3, KAT8, TBX21, BHLHE40, NFKBIZ, AR, TAF1, ZBTB16, ZBTB40, ARID4B, EGR1, HSF1, NCOR1, IKZF2, BRD4, JUND, NOTCH3, SCRT1, ZBTB26, AHR

Target gene symbol (double-evidenced CRMs): C21orf91,USP25

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000155313, ENSG00000154642,

eachgene

Deatailed information for cohesin site CDBP00414041