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Basic information

CohesinDB ID: CDBP00414047

Locus: chr21-17793333-17794084

Data sourse: ENCSR000DZP, ENCSR000BLY, GSE206145, GSE206145-NatGen2015, ENCSR000BMY, ENCSR000EHX, GSE120943

Cell type: Fibroblast, Monocytes, GM12878, SK-N-SH, B-cell

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: Mau2,SMC3,Rad21,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 47% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 25%, "1_TssA": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NKX2-2, MYCN, CHD2, SOX2, PAF1, CREM, MTA2, STAT1, FOXA1, CDK9, TWIST1, SMARCC1, KDM1A, YY1, RELA, ZNF19, IRF2, JUNB, NEUROD1, RUNX2, MYC, ZFP64, GATA4, NFIC, ISL1, RAD21, GRHL3, SKIL, ARNT, RUNX3, OTX2, GATA3, ATF2, GABPA, BATF, STAT3, MAX, PBX3, ETV6, SUPT5H, GATA1, RCOR1, IKZF1, HAND2, MED1, CDK8, NR3C1, KMT2A, ZNF217, ESR1, PITX3, EBF3, PHOX2B, CTCF, TCF12, JUN, EP300, SPI1, TBX21, AR, IRF1, GATA2, IRF4, ATF7, ASH2L, IKZF2, BRD4, JUND, HEXIM1-CDK9, TEAD4, TBX2, MLLT1

Target gene symbol (double-evidenced CRMs): USP25,C21orf91

Function elements

Human SNPs: .

Number of somatic mutations (coding): 120

Number of somatic mutations (non-coding): 40

Related genes and loops

Related gene: ENSG00000155313, ENSG00000154642,

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Deatailed information for cohesin site CDBP00414047