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Basic information

CohesinDB ID: CDBP00415208

Locus: chr21-25349636-25351281

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE126634, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, GSE165895, ENCSR000EFJ, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE115250, GSE138405, GSE86191, GSE101921, GSE135093, GSE152721, GSE120943, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, GSE118494, GSE76815, ENCSR000EHW, GSE85526, ENCSR000ECE, GSE206145, ENCSR000BMY, ENCSR000EHX, GSE97394, GSE105004, GSE110061, GSE129526, ENCSR000HPG, GSE155324, ENCSR000EDE, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE38411

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, GM19193, HAP1, GM19099, HUES64, MCF-7, GM12892, THP-1, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, HUVEC, GM19238, HeLa, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 34% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.411

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 35% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 92%, "9_Het": 3%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, SMC1A, FOXA2, POU5F1, TOP2A, SOX2, ZSCAN16, GTF2B, DUX4, SMAD3, FOXA1, FOXF1, SRF, ZNF654, DDX5, SUZ12, HOXB13, HOXC5, YY1, RELA, ZBTB2, ERG, JUNB, MYC, RUNX2, GATA4, CTCFL, RAD21, NKX2-1, TAL1, ZNF143, TLE3, TCF7L2, PIAS1, ESR1, PHOX2B, CTCF, JUN, BRD2, SPI1, BCL11A, ZHX2, GATA2, EGLN2, BRD4, SMC1, SMC3, STAG1

Target gene symbol (double-evidenced CRMs): MRPL39,APP

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 16

Related genes and loops

Related gene: ENSG00000154719, ENSG00000142192,

eachgene

Deatailed information for cohesin site CDBP00415208