- Basic information
- CohesinDB ID: CDBP00415227
- Locus: chr21-25451270-25452779
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Data sourse: ENCSR000EFJ, GSE138405, GSE206145-NatGen2015, GSE120943, GSE68388, GSE126990, GSE50893, GSE165895
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Cell type: GM2630, Fibroblast, Hela-Kyoto, Monocytes, GM2610, IMR-90, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
35% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 86%,
"7_Enh": 7%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PPARG, MYCN, EBF1, SIN3A, NME2, XBP1, ZSCAN16, FOXA1, HOXC5, RELA, NFIC, MYC, RUNX2, RAD21, PBX4, DAXX, OTX2, GATA3, BATF, GABPA, STAT3, PBX3, MAX, FOS, NR3C1, CEBPB, PIAS1, KDM5B, PHOX2B, JUN, TCF12, MAFK, EP300, ZHX2, BHLHE40, MNT, GATA2, BRD4, FOSL2
- Target gene symbol (double-evidenced CRMs): ATP5PF,JAM2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 17
- Related genes and loops
- Related gene:
ENSG00000154721,
ENSG00000154723,
- Related loop:
chr21:14525000-14550000~~chr21:25450000-25475000,
chr21:17775000-17800000~~chr21:25450000-25475000,
chr21:25420786-25422730~~chr21:25455832-25458166,
chr21:25423746-25424928~~chr21:25455834-25458451,
chr21:25425000-25450000~~chr21:25550000-25575000,
chr21:25425000-25450000~~chr21:25700000-25725000,
chr21:25450000-25475000~~chr21:25550000-25575000,
chr21:25450000-25475000~~chr21:25700000-25725000,
chr21:25450000-25475000~~chr21:29225000-29250000,
chr21:25450000-25475000~~chr21:38225000-38250000,
chr21:25455832-25458166~~chr21:25501013-25503266,
chr21:25455834-25458451~~chr21:25486329-25488255,
chr21:25455834-25458451~~chr21:25572455-25574658,