- Basic information
- CohesinDB ID: CDBP00415230
- Locus: chr21-25459433-25460303
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Data sourse: GSE93080, ENCSR000DZP, GSE206145, GSE62063, GSE50893
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Cell type: GM12878, SNYDER, Ramos, B-cell
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: NIPBL,SA1,Rad21,SMC1,Mau2,SMC3
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
35% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 83%,
"5_TxWk": 7%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, CBX5, E2F7, NME2, XBP1, FOXA1, SUZ12, HDGF, TSC22D4, BMI1, NFIC, RUNX3, PRDM1, CBFB, PAX5, BACH2, MAF, JMJD1C, ELF1, BCLAF1, TEAD1, KLF6, ZNF217, MLL, TP73, HNF1B, OCA2, USF2, CTCF, JUN, SND1, EP300, TCF12, BAF155, DPF2, IRF4, RFX5, TRIM24, RAD51, TEAD4, KMT2B, RBPJ, EED, POU2F2, BRD3, TOP2A, MTA2, DUX4, STAT1, SRF, NBN, ARID3A, TBP, ERG, CHD4, ZNF597, NFKB2, ETS1, MYC, RAD21, GRHL3, RXRA, BATF3, GABPA, STAT3, IKZF1, CD74, VDR, NR3C1, CEBPB, STAT5B, KMT2A, CREB1, TBL1XR1, EZH2, SPI1, IRF1, HDAC2, GATA2, DRAP1, MXI1, SMARCA5, RELB, RUNX1, CIITA, SMC1A, BCL6, AFF4, ZFX, SMAD3, ERG3, TRIM22, SMARCC1, ZNF18, MEF2A, CREBBP, ZBTB2, ZNF384, IRF2, RUNX2, CDK6, ARNT, DAXX, PBX4, BACH1, ATF2, PRDM9, FOXM1, ETV6, PBX3, FOS, CDK8, MED1, ZEB1, PML, CEBPD, MYB, PIAS1, SMAD1, ZMYM3, STAT5A, ZNF22, MAFK, BCL11A, SP1, NIPBL, REST, ATF7, ASH2L, TCF3, FOXP1, PRDM6, STAT2, NCOR2, MLLT1, NFATC3, MEF2B, ZNF207, MTA3, CREM, EBF1, NFATC1, E2F8, CHD2, MEIS1, GTF2B, ZBED1, MEF2C, TCF7, CDK9, BCL3, YY1, RELA, TARDBP, NEUROD1, JUNB, ISL1, TCF4, SKIL, HIF1A, ZFP36, OTX2, GATA3, BATF, TAL1, MAX, SPIB, KLF4, ZNF592, NR2F2, NR2F1, ZNF687, PKNOX1, TP53, MED, ZNF334, NFKB1, PHOX2B, TBX21, BHLHE40, AR, TAF1, RXR, IKZF2, BRD4, JUND, CLOCK, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): JAM2,ATP5PF
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000154721,
ENSG00000154723,
- Related loop:
chr21:14525000-14550000~~chr21:25450000-25475000,
chr21:17775000-17800000~~chr21:25450000-25475000,
chr21:25420786-25422730~~chr21:25455832-25458166,
chr21:25423746-25424928~~chr21:25455834-25458451,
chr21:25450000-25475000~~chr21:25550000-25575000,
chr21:25450000-25475000~~chr21:25700000-25725000,
chr21:25450000-25475000~~chr21:29225000-29250000,
chr21:25450000-25475000~~chr21:38225000-38250000,
chr21:25455832-25458166~~chr21:25501013-25503266,
chr21:25455834-25458451~~chr21:25486329-25488255,
chr21:25455834-25458451~~chr21:25572455-25574658,
chr21:25458986-25460259~~chr21:25486634-25488226,