- Basic information
- CohesinDB ID: CDBP00415369
- Locus: chr21-25997796-25999512
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Data sourse: ENCSR000BLD, ENCSR000BTU, ENCSR230ZWH, GSE126634, GSE129526, ENCSR000BLY, GSE105028, GSE152721, ENCSR000ECE, GSE206145, GSE116344, GSE97394, GSE64758, ENCSR917QNE
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Cell type: RPE, H1-hESC, HCT-116, RH4, Ishikawa, H9-hESC, SK-N-SH, Liver, HAP1, HUES64
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: NIPBL,Rad21,Mau2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 40%,
"7_Enh": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, HMG20A, SOX2, XBP1, FOXA1, RXRB, MLL4, TFAP4, NFIC, CHD7, ATF4, MORC2, CDX2, MYOG, KLF5, TEAD1, ELF1, TRIM28, KLF6, SNAI2, RCOR2, ESR1, LMO2, CTCF, TCF12, EP300, SOX9, SOX5, GATA6, TEAD4, FOXA3, GATAD2A, PDX1, RBPJ, TFAP2C, NANOG, BRD1, POU5F1, MYCN, ZBTB48, DUX4, SAP130, SP4, TBP, HOXC5, ERG, ASCL1, ETS1, MYC, ONECUT1, SMARCA4, EOMES, RAD21, GRHL3, RXRA, PROX1, NKX2-1, STAT3, ZNF614, SOX10, XRCC5, NR2F6, ARNTL, NR3C1, ZNF750, CEBPB, HNRNPL, CREB1, GRHL2, SPI1, TFE3, IRF1, HDAC2, GATA2, ZNF644, FLI1, DRAP1, ZGPAT, NFIL3, ZIM3, ETV5, RUNX1, BCL6, SMC1A, CEBPA, EZH2phosphoT487, SOX13, SIN3A, ZFX, SMAD3, SMARCC1, ZBTB2, NFYC, ZNF384, CDK6, GATA4, PBX4, ATF2, PRDM9, SMAD4, FOXM1, CHD1, CDK8, MED1, ZEB1, TEAD3, MYB, RBM22, NIPBL, SP1, BCL11A, HNF4A, POU2F3, ASH2L, CTBP2, PHIP, BCOR, FOXP1, SMC3, NCOR2, STAG1, PPARG, FOXA2, RBBP5, CHD2, PAF1, TCF7, CDK9, HOXB13, KDM1A, YY1, RELA, NEUROD1, SP140, OTX2, GATA3, TAL1, MAX, GATA1, KLF4, CEBPG, BCL11B, NCOA3, NR2F2, TCF7L2, KDM5B, TP53, MYOD1, PHOX2B, T, ELF3, KAT8, TBX21, BHLHE40, AR, TAF1, NOTCH3, BRD4, JUND, MAZ, FOSL2
- Target gene symbol (double-evidenced CRMs): MRPL39,APP
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 208
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000154719,
ENSG00000142192,
- Related loop:
chr21:25600000-25625000~~chr21:25975000-26000000,
chr21:25600000-25625000~~chr21:26000000-26025000,
chr21:25606914-25609560~~chr21:26000712-26002239,
chr21:25875000-25900000~~chr21:25975000-26000000,
chr21:25880643-25882866~~chr21:26000836-26002126,
chr21:25880833-25882973~~chr21:25999508-26002814,
chr21:25880878-25883186~~chr21:26000596-26002821,
chr21:25880879-25883157~~chr21:25999375-26002832,
chr21:25880888-25882763~~chr21:26000649-26002298,
chr21:25894872-25896862~~chr21:25999375-26002832,
chr21:25895093-25897256~~chr21:26000596-26002821,
chr21:25895184-25896718~~chr21:25999508-26002814,
chr21:25975000-26000000~~chr21:26100000-26125000,
chr21:25975000-26000000~~chr21:26150000-26175000,
chr21:26000000-26025000~~chr21:26325000-26350000,
chr21:26000000-26025000~~chr21:26700000-26725000,