- Basic information
- CohesinDB ID: CDBP00415588
- Locus: chr21-26880078-26883925
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Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, GSE126634, ENCSR000BLY, ENCSR404BPV, GSE105028, ENCSR000ECS, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE122299, GSE115250, GSE138405, GSE101921, GSE135093, GSE152721, GSE120943, ENCSR198ZYJ, GSE206145-NatGen2015, GSE112028, GSE130135, GSE116344, GSE106870, GSE138105, GSE145327, GSE94872, GSE98367, ENCSR000EHW, GSE155828, ENCSR000ECE, GSE85526, GSE206145, ENCSR000EHX, GSE97394, GSE55407, ENCSR000BTQ, ENCSR000HPG, GSE155324, ENCSR000EDE, GSE83726, GSE126990, GSE50893, ENCSR748MVX, GSE131577
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Cell type: MDM, RH4, GM2610, SLK, CVB-hiPSC, Liver, Transformed-RPE1, TC-32, H9-hESC, RPE, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, DKO, H1-hESC, SNYDER, Monocytes, Lymphoblast, SK-N-SH, HeLa-Tet-On, THP-1, Macrophage, HUES64, MCF-7, Hela-Kyoto, HL-60, HEK293T, Neurons-H1, A-549, HUVEC, HCAEC, CNCC-WT33iPSC, OCI-AML-3, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 32% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.578
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
40% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 78%,
"7_Enh": 10%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NANOG, PGR, FOXA2, ZNF317, STAT1, FOXA1, HOXB13, SMARCC1, ERG, CREBBP, USP7, ONECUT1, GATA4, ARNT, HIF1A, GATA3, STAT3, MAX, NRIP1, NKX3-1, TLE3, ESRRA, TEAD1, TRIM28, PIAS1, ESR1, SETDB1, BAF155, AR, PAX8, GATA2, EGLN2, BRD4, SMC3
- Target gene symbol (double-evidenced CRMs): ADAMTS5
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 38
- Related genes and loops
- Related gene:
ENSG00000154736,
- Related loop:
chr21:26875000-26900000~~chr21:27200000-27225000,
chr21:26875000-26900000~~chr21:27300000-27325000,
chr21:26875000-26900000~~chr21:27325000-27350000,
chr21:26875000-26900000~~chr21:27550000-27575000,
chr21:26875000-26900000~~chr21:27675000-27700000,
chr21:26875000-26900000~~chr21:28225000-28250000,
chr21:26880663-26882691~~chr21:27564041-27565758,
chr21:26880663-26882691~~chr21:27700355-27702199,
chr21:26880663-26882691~~chr21:27802305-27803923,
chr21:26880679-26882832~~chr21:27699929-27702131,
chr21:26880713-26882657~~chr21:27563683-27565992,
chr21:26880725-26882738~~chr21:27476214-27477477,
chr21:26880733-26882858~~chr21:27699551-27702135,
chr21:26880733-26882858~~chr21:27703428-27704636,
chr21:26880766-26882640~~chr21:27563925-27566163,
chr21:26880869-26882702~~chr21:27465683-27467004,
chr21:26880869-26882702~~chr21:27564068-27565806,
chr21:26880869-26882702~~chr21:27700318-27702132,
chr21:26880905-26882638~~chr21:27700358-27702051,
chr21:26880923-26882670~~chr21:27700028-27702259,
chr21:26880942-26882759~~chr21:26960974-26962592,
chr21:26880999-26882442~~chr21:27700129-27702131,
chr21:26881095-26882278~~chr21:27802335-27803696,