Deatailed information for gene ENSG00000154736
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00009795
- Gene Symbol: ADAMTS5
- Ensembl ID: ENSG00000154736
-
Gene locus: chr21:26917921-26967088
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-25652526-25652691,
chr21-25658229-25659074,
chr21-25660159-25660645,
chr21-25664270-25664549,
chr21-25670626-25671144,
chr21-26754901-26755319,
chr21-26756401-26757018,
chr21-26761360-26762618,
chr21-26764343-26764463,
chr21-26765149-26765417,
chr21-26765908-26766700,
chr21-26767730-26768147,
chr21-26768608-26771257,
chr21-26824624-26825033,
chr21-26826754-26827193,
chr21-26832682-26836085,
chr21-26836642-26836862,
chr21-26837135-26838300,
chr21-26839542-26841526,
chr21-26841743-26847812,
chr21-26848196-26852813,
chr21-26853060-26853350,
chr21-26854502-26857883,
chr21-26858097-26858651,
chr21-26867750-26868009,
chr21-26871783-26872605,
chr21-26880078-26883925,
chr21-26914515-26914770,
chr21-26917803-26919602,
chr21-26919999-26920614,
chr21-26934483-26934858,
chr21-26937952-26938250,
chr21-26938947-26942644,
chr21-26943437-26944214,
chr21-26945787-26946495,
chr21-26946875-26947679,
chr21-26948229-26948588,
chr21-26949868-26950099,
chr21-26951560-26951869,
chr21-26952332-26953074,
chr21-26954207-26955169,
chr21-26958780-26959264,
chr21-26961136-26968924,
chr21-27101424-27102041,
chr21-27104794-27105819,
chr21-27108104-27108760,
chr21-27110966-27111230,
chr21-27111585-27112109,
chr21-27116200-27116516,
chr21-27122600-27123188,
chr21-27201219-27202078,
chr21-27202334-27203054,
chr21-27206351-27206965,
chr21-27212161-27212411,
chr21-27212637-27214873,
chr21-27215313-27215599,
chr21-27218751-27221382,
chr21-27223327-27223993,
chr21-27224651-27225725,
chr21-27299811-27301698,
chr21-27302530-27302899,
chr21-27305606-27308114,
chr21-27315387-27315916,
chr21-27358449-27359776,
chr21-27360029-27360926,
chr21-27362042-27362950,
chr21-27363618-27364538,
chr21-27365063-27366378,
chr21-27370966-27371406,
chr21-27371620-27373080,
chr21-27379385-27379783,
chr21-27380072-27380846,
chr21-27382417-27382721,
chr21-27385020-27385446,
chr21-27387994-27388130,
chr21-27392112-27392323,
chr21-27393159-27393938,
chr21-27456236-27456444,
chr21-27458848-27459210,
chr21-27464634-27465158,
chr21-27465427-27465909,
chr21-27466171-27466657,
chr21-27468389-27468764,
chr21-27470971-27471385,
chr21-27475441-27478394,
chr21-27555979-27556487,
chr21-27557265-27557849,
chr21-27561020-27561913,
chr21-27563002-27566992,
chr21-27567650-27574605,
chr21-27589180-27591051,
chr21-27671283-27676296,
chr21-27677315-27678192,
chr21-27679599-27679830,
chr21-27680983-27682358,
chr21-27691546-27691856,
chr21-27692891-27694043,
chr21-27694325-27695497,
chr21-27696845-27697019,
chr21-27697831-27705094,
chr21-27719405-27719658,
chr21-27722043-27722380,
chr21-28325514-28326311,
chr21-28332778-28340251,
chr21-28341277-28341586,
chr21-28342232-28342714,
chr21-28343843-28344097,
chr21-28726042-28726237,
chr21-28728325-28728960,
chr21-28730369-28730658,
chr21-28734874-28735184,
chr21-28737724-28738809,
chr21-28739033-28739334,
chr21-28740627-28747447,
chr21-28749634-28749909,
chr21-28750506-28751239,
chr21-28754026-28755278,
chr21-28761675-28762116,
chr21-28763422-28763635,
chr21-28770813-28772668,
chr21-28773018-28773359,
-
Co-expression with cohesin genes Rho = 0.4906
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.631
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.910
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: iPSC,ARPE-19,H9-endodermal,Skin-Fibroblast,K-562,Kelly,H1-hESC,HFF-hTERT,HAP1,HFFc6,PAEC,HeLa-S3,K1,H1-Trophectoderm,H9-hESC,H1-Mesenchymal,H1-Mesendoderm,HUES64
- Related loop:
chr21:17450000-17475000~~chr21:26925000-26950000,
chr21:25650000-25675000~~chr21:26925000-26950000,
chr21:26750000-26775000~~chr21:26950000-26975000,
chr21:26825000-26850000~~chr21:26925000-26950000,
chr21:26850000-26875000~~chr21:26950000-26975000,
chr21:26880942-26882759~~chr21:26960974-26962592,
chr21:26900000-26925000~~chr21:27200000-27225000,
chr21:26900000-26925000~~chr21:27550000-27575000,
chr21:26900000-26925000~~chr21:28325000-28350000,
chr21:26925000-26950000~~chr21:27100000-27125000,
chr21:26925000-26950000~~chr21:27200000-27225000,
chr21:26925000-26950000~~chr21:27300000-27325000,
chr21:26925000-26950000~~chr21:27375000-27400000,
chr21:26925000-26950000~~chr21:27550000-27575000,
chr21:26932823-26934519~~chr21:26951979-26953930,
chr21:26939108-26940527~~chr21:27589432-27591275,
chr21:26950000-26975000~~chr21:27200000-27225000,
chr21:26950000-26975000~~chr21:27350000-27375000,
chr21:26950000-26975000~~chr21:27450000-27475000,
chr21:26950000-26975000~~chr21:27550000-27575000,
chr21:26950000-26975000~~chr21:27675000-27700000,
chr21:26950000-26975000~~chr21:27700000-27725000,
chr21:26950000-26975000~~chr21:28325000-28350000,
chr21:26950000-26975000~~chr21:28725000-28750000,
chr21:26950000-26975000~~chr21:28750000-28775000,
chr21:26963690-26966148~~chr21:27475507-27477823,
chr21:26963690-26966148~~chr21:27563536-27566212,
chr21:26963690-26966148~~chr21:27699551-27702135,
chr21:26964017-26968392~~chr21:27474660-27477802,
chr21:26964017-26968392~~chr21:27699511-27702311,
chr21:26964890-26966428~~chr21:27212930-27214316,
chr21:26964959-26966539~~chr21:27212783-27214490,
chr21:26965332-26968340~~chr21:27212947-27214217,
chr21:26965332-26968340~~chr21:27699963-27702208,
chr21:26966496-26968374~~chr21:27475507-27477823,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFI8649RQJ, 4DNFIQYQWPF5, 4DNFI3CFMRID, GSE95015, 4DNFIWZEN3FF, 4DNFIDJ2JZ7Q, 4DNFIMROE6N4, 4DNFI5SUHCGZ, GSE120294, GSE103148, 4DNFI7H4II2V, 4DNFIILDWK8M, ENCSR732QOH, ENCSR478BMT, 4DNFIBM714BP, ENCSR668RDP, GSE97394, 4DNFIIMZB6Y9, 4DNFIE8T8JZ8, GSE52457, 4DNFIBT4EAKN, 4DNFI3A3VYWU, 4DNFIM2BMJ33, Direct, ENCSR314HAC, 4DNFI6XD6JAQ, 4DNFISPUVQHA, 4DNFIAS8LV1C, 4DNFI6JJQKFJ, 4DNFI8JFOAJT, 4DNFIC3HAU11, ENCSR110JOO, 4DNFI2J1ODWB, 4DNFIFLJLIS5, GSE105028, 4DNFIDBIEXI7, 4DNFII84FBKM, 4DNFIVSCH2CH
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: SLK,OCI-AML-3,K-562,CMK,U2OS,HeLa-S3
- Cohesin-DEGs, number of studies: 8
- Cohesin-DEGs, study: GSE139845,GSE111537,GSE154086,GSE131448,GSE138937,GSE89799,GSE130558
- Cohesin-DEGs, subunit: WAPL,CTCF,Rad21,SA2