- Basic information
- CohesinDB ID: CDBP00415556
- Locus: chr21-26768608-26771257
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Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE126634, ENCSR760NPX, GSE25021, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE105028, GSE103477, GSE111537, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE165895, GSE93080, GSE115250, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE135093, GSE152721, ENCSR198ZYJ, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE116344, GSE138105, GSE145327, GSE94872, ENCSR895JMI, ENCSR000EEG, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR000EHW, GSE85526, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR853VWZ, ENCSR956LGB, GSE62063, ENCSR944ZCT, GSE131956, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, GSE68388, GSE206145, GSE126990, GSE50893, ENCSR000ECS, GSE131577
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Cell type: MDM, RH4, SLK, Liver, TC-32, HuCC-T1, H9-hESC, RPE, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, GM2255, IMR-90, HFFc6, DKO, H1-hESC, SNYDER, GM12878, GBM39, SK-N-SH, RT-112, HeLa-Tet-On, THP-1, Macrophage, HUES64, MCF-7, Ramos, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, HeLa, OCI-AML-3, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 44% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.522
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
41% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 89%,
"7_Enh": 5%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: GABPA, HIF1A
- Target gene symbol (double-evidenced CRMs): ADAMTS1,LINC00113,ADAMTS5
- Function elements
- Human SNPs: Parental_extreme_longevity_(95_years_and_older)
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 28
- Related genes and loops
- Related gene:
ENSG00000154734,
ENSG00000154736,
ENSG00000225298,
- Related loop:
chr21:26750000-26775000~~chr21:26950000-26975000,
chr21:26750000-26775000~~chr21:27700000-27725000,
chr21:26750000-26775000~~chr21:28025000-28050000,
chr21:26750000-26775000~~chr21:28325000-28350000,
chr21:26750000-26775000~~chr21:28725000-28750000,
chr21:26750000-26775000~~chr21:28925000-28950000,
chr21:26768397-26771044~~chr21:26840431-26841710,
chr21:26768427-26770708~~chr21:26842624-26843855,
chr21:26768475-26770735~~chr21:27700023-27702186,
chr21:26768631-26771060~~chr21:27700355-27702199,
chr21:26768665-26770424~~chr21:27699913-27702170,
chr21:26768676-26770716~~chr21:26833331-26835927,
chr21:26768928-26771044~~chr21:26833230-26835582,
chr21:26768979-26770511~~chr21:27700287-27702114,
chr21:26768979-26770792~~chr21:27213020-27214262,
chr21:26769208-26770436~~chr21:27700042-27701914,
chr21:26769270-26770477~~chr21:27700358-27702051,