Deatailed information for gene ENSG00000154734
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00009794
- Gene Symbol: ADAMTS1
- Ensembl ID: ENSG00000154734
-
Gene locus: chr21:26835754-26845409
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-25024339-25025139,
chr21-25026039-25026539,
chr21-25036675-25037042,
chr21-25039299-25040740,
chr21-25041710-25041829,
chr21-25042314-25042456,
chr21-25375559-25376065,
chr21-25383848-25387605,
chr21-25387847-25388717,
chr21-25395973-25396887,
chr21-25399514-25400754,
chr21-25600851-25601124,
chr21-25606719-25610187,
chr21-25614176-25615182,
chr21-25624549-25624749,
chr21-25626132-25626377,
chr21-25626696-25627327,
chr21-25638808-25641127,
chr21-25642332-25642777,
chr21-25646355-25647152,
chr21-25647707-25648230,
chr21-25731829-25732870,
chr21-25733103-25733519,
chr21-25733724-25736727,
chr21-25875158-25875785,
chr21-25877272-25877556,
chr21-25878883-25884507,
chr21-25886456-25886884,
chr21-25887111-25887606,
chr21-25887958-25888558,
chr21-25890135-25890660,
chr21-25895168-25897778,
chr21-25898579-25899047,
chr21-26150217-26150652,
chr21-26151334-26152383,
chr21-26153595-26154542,
chr21-26154777-26155253,
chr21-26158881-26159268,
chr21-26159924-26160609,
chr21-26162072-26162427,
chr21-26162939-26163160,
chr21-26163946-26164899,
chr21-26165409-26165563,
chr21-26165938-26172090,
chr21-26172443-26173621,
chr21-26702109-26702704,
chr21-26709227-26709736,
chr21-26714761-26718662,
chr21-26718980-26720367,
chr21-26721013-26721255,
chr21-26721627-26722108,
chr21-26731078-26733640,
chr21-26737504-26738146,
chr21-26747114-26747560,
chr21-26748116-26748489,
chr21-26768608-26771257,
chr21-26832682-26836085,
chr21-26836642-26836862,
chr21-26837135-26838300,
chr21-26839542-26841526,
chr21-26841743-26847812,
chr21-26848196-26852813,
chr21-26934483-26934858,
chr21-26937952-26938250,
chr21-26938947-26942644,
chr21-26943437-26944214,
chr21-26945787-26946495,
chr21-26946875-26947679,
chr21-26948229-26948588,
chr21-26949868-26950099,
chr21-26951560-26951869,
chr21-26952332-26953074,
chr21-26954207-26955169,
chr21-26958780-26959264,
chr21-26961136-26968924,
chr21-26972162-26972628,
chr21-27023138-27026303,
chr21-27026520-27027066,
chr21-27030460-27030801,
chr21-27036692-27036976,
chr21-27045002-27045130,
chr21-27046439-27048534,
chr21-27049110-27049535,
chr21-27077262-27078028,
chr21-27085038-27085250,
chr21-27090769-27091057,
chr21-27094126-27094788,
chr21-27181983-27182203,
chr21-27186225-27186557,
chr21-27186807-27186964,
chr21-27189506-27191386,
chr21-27192321-27192764,
chr21-27201219-27202078,
chr21-27202334-27203054,
chr21-27206351-27206965,
chr21-27212161-27212411,
chr21-27212637-27214873,
chr21-27215313-27215599,
chr21-27218751-27221382,
chr21-27223327-27223993,
chr21-27224651-27225725,
chr21-27226483-27226803,
chr21-27239146-27239360,
chr21-27240871-27241288,
chr21-27244102-27245513,
chr21-27245741-27245899,
chr21-27246186-27247365,
chr21-27299811-27301698,
chr21-27302530-27302899,
chr21-27305606-27308114,
chr21-27315387-27315916,
chr21-27358449-27359776,
chr21-27360029-27360926,
chr21-27362042-27362950,
chr21-27363618-27364538,
chr21-27365063-27366378,
chr21-27370966-27371406,
chr21-27371620-27373080,
chr21-27406043-27406706,
chr21-27407757-27408086,
chr21-27408945-27409285,
chr21-27412847-27413181,
chr21-27416164-27417202,
chr21-27419173-27419550,
chr21-27420376-27420983,
chr21-27421200-27426298,
chr21-27429416-27430640,
chr21-27431524-27431889,
chr21-27445825-27445967,
chr21-27448270-27449349,
chr21-27456236-27456444,
chr21-27458848-27459210,
chr21-27464634-27465158,
chr21-27465427-27465909,
chr21-27466171-27466657,
chr21-27468389-27468764,
chr21-27470971-27471385,
chr21-27475441-27478394,
chr21-27479348-27479900,
chr21-27480366-27481430,
chr21-27482997-27483335,
chr21-27498058-27498590,
chr21-27555979-27556487,
chr21-27557265-27557849,
chr21-27561020-27561913,
chr21-27563002-27566992,
chr21-27567650-27574605,
chr21-27579731-27583586,
chr21-27583803-27585452,
chr21-27585872-27588931,
chr21-27589180-27591051,
chr21-27647482-27650467,
chr21-27660459-27660955,
chr21-27671283-27676296,
chr21-27677315-27678192,
chr21-27679599-27679830,
chr21-27680983-27682358,
chr21-27691546-27691856,
chr21-27692891-27694043,
chr21-27694325-27695497,
chr21-27696845-27697019,
chr21-27697831-27705094,
chr21-27719405-27719658,
chr21-27722043-27722380,
chr21-27758206-27760949,
chr21-27802628-27804018,
chr21-28025094-28025504,
chr21-28042682-28043085,
chr21-28048260-28048549,
chr21-28050232-28054706,
chr21-28055025-28055673,
chr21-28057219-28057369,
chr21-28058256-28059473,
chr21-28060090-28060269,
chr21-28062272-28062979,
chr21-28064474-28066923,
chr21-28067534-28068121,
chr21-28068492-28070097,
chr21-28206765-28208867,
chr21-28213315-28213616,
chr21-28214838-28216276,
chr21-28217115-28217363,
chr21-28220723-28221224,
chr21-28227105-28227445,
chr21-28227896-28231619,
chr21-28234195-28235962,
chr21-28237523-28237929,
chr21-28239422-28239738,
chr21-28240623-28241036,
chr21-28247181-28248074,
chr21-28307232-28307473,
chr21-28308206-28308932,
chr21-28311303-28312111,
chr21-28313765-28313983,
chr21-28316832-28317629,
chr21-28317994-28318324,
chr21-28324455-28324516,
chr21-28325514-28326311,
chr21-28332778-28340251,
chr21-28341277-28341586,
chr21-28342232-28342714,
chr21-28343843-28344097,
chr21-28426062-28428543,
chr21-28430646-28433389,
chr21-28435933-28437451,
chr21-28439119-28440662,
chr21-28441650-28446617,
chr21-28446900-28448101,
chr21-28501658-28501980,
chr21-28509074-28509343,
chr21-28515785-28518121,
chr21-28518339-28518971,
chr21-28519958-28520245,
chr21-28520608-28523119,
chr21-28523395-28523853,
chr21-28536526-28542170,
chr21-28543998-28544380,
chr21-28547810-28548217,
chr21-28549840-28550779,
chr21-28554707-28555498,
chr21-28563147-28564196,
chr21-28569434-28569573,
chr21-28572754-28572984,
chr21-28581117-28581680,
chr21-28587521-28588238,
chr21-28589885-28590379,
chr21-28590711-28591217,
chr21-28595856-28596319,
chr21-28626740-28628205,
chr21-28628505-28628838,
chr21-28631051-28640482,
chr21-28641665-28643259,
chr21-28644180-28645338,
chr21-28726042-28726237,
chr21-28728325-28728960,
chr21-28730369-28730658,
chr21-28734874-28735184,
chr21-28737724-28738809,
chr21-28739033-28739334,
chr21-28740627-28747447,
chr21-28749634-28749909,
chr21-28750506-28751239,
chr21-28754026-28755278,
chr21-28761675-28762116,
chr21-28763422-28763635,
chr21-28770813-28772668,
chr21-28773018-28773359,
-
Co-expression with cohesin genes Rho = 0.4161
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.604
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.895
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: H9-endodermal,IMR-90,MCF-10A,TAMR-MCF7,MB157,DU145,Keratinocytes192627,GM12892,K1,hTERT-HME1,H1-Mesenchymal,H1-Mesendoderm,Olfactory,Hepatocyte-H9,MCF-7,GM12891,SARS-Cov2-olfactory,GM12878,MSiPS,K-562,Naive-hESC,A-549,CyT49-pancreatic,HFFc6,PAEC,HeLa-S3,LNCaP,H1-Trophectoderm,SU-DHL-2,H9-hESC,KU-19-19,Hippocampus,Primed-hESC,NCI-H1437,iPSC,REC-1,ARPE-19,HCT-116,OCI-AML-3,Hep-G2,HT-1197,Kelly,H1-hESC,HCC1599,GM19238,HT-1376,Motor-Neuron,MSLCL,NaiveB,U-937,HUES64,SU-DHL-4,H1-NPC,CyT49-hESC,HUVEC,HL-60,NPC-H9,CyT49-endoderm,RT-112,Skin-Fibroblast,KBM-7,Jurkat,CyT49-Gut,CC-2551,HAP1,HFF-hTERT
- Related loop:
chr21:23400000-23425000~~chr21:26825000-26850000,
chr21:25025000-25050000~~chr21:26825000-26850000,
chr21:25375000-25400000~~chr21:26825000-26850000,
chr21:25600000-25625000~~chr21:26825000-26850000,
chr21:25625000-25650000~~chr21:26825000-26850000,
chr21:25725000-25750000~~chr21:26825000-26850000,
chr21:25875000-25900000~~chr21:26825000-26850000,
chr21:26150000-26175000~~chr21:26825000-26850000,
chr21:26700000-26725000~~chr21:26825000-26850000,
chr21:26725000-26750000~~chr21:26825000-26850000,
chr21:26768397-26771044~~chr21:26840431-26841710,
chr21:26768427-26770708~~chr21:26842624-26843855,
chr21:26768676-26770716~~chr21:26833331-26835927,
chr21:26768928-26771044~~chr21:26833230-26835582,
chr21:26825000-26850000~~chr21:26925000-26950000,
chr21:26825000-26850000~~chr21:27550000-27575000,
chr21:26825000-26850000~~chr21:27675000-27700000,
chr21:26825000-26850000~~chr21:27700000-27725000,
chr21:26825000-26850000~~chr21:28025000-28050000,
chr21:26825000-26850000~~chr21:28050000-28075000,
chr21:26825000-26850000~~chr21:28200000-28225000,
chr21:26825000-26850000~~chr21:28225000-28250000,
chr21:26825000-26850000~~chr21:28325000-28350000,
chr21:26825000-26850000~~chr21:28425000-28450000,
chr21:26825000-26850000~~chr21:28500000-28525000,
chr21:26825000-26850000~~chr21:28525000-28550000,
chr21:26825000-26850000~~chr21:28575000-28600000,
chr21:26825000-26850000~~chr21:28625000-28650000,
chr21:26825000-26850000~~chr21:28725000-28750000,
chr21:26825000-26850000~~chr21:28750000-28775000,
chr21:26825000-26850000~~chr21:28925000-28950000,
chr21:26825000-26850000~~chr21:28950000-28975000,
chr21:26825000-26850000~~chr21:30175000-30200000,
chr21:26833453-26834965~~chr21:27700355-27702199,
chr21:26848648-26851445~~chr21:27564056-27565671,
chr21:26848648-26851445~~chr21:27700287-27702114,
chr21:26848655-26851362~~chr21:27563683-27565992,
chr21:26848655-26851362~~chr21:27673391-27674734,
chr21:26848655-26851362~~chr21:27700015-27702372,
chr21:26848657-26851571~~chr21:27563649-27565742,
chr21:26848657-26851571~~chr21:27700129-27702131,
chr21:26848663-26851399~~chr21:27564063-27565968,
chr21:26848663-26851399~~chr21:27700279-27702131,
chr21:26848676-26851554~~chr21:27700282-27702347,
chr21:26848685-26851208~~chr21:27700325-27702096,
chr21:26848686-26851632~~chr21:27563536-27566212,
chr21:26848686-26851632~~chr21:27699551-27702135,
chr21:26848688-26851432~~chr21:27700355-27702199,
chr21:26848688-26851432~~chr21:27802305-27803923,
chr21:26848701-26852142~~chr21:27474660-27477802,
chr21:26848701-26852142~~chr21:27699511-27702311,
chr21:26848717-26851115~~chr21:27700284-27702122,
chr21:26848717-26851115~~chr21:27802133-27803841,
chr21:26848717-26851211~~chr21:27700526-27702055,
chr21:26848717-26851211~~chr21:27802381-27803695,
chr21:26848718-26851536~~chr21:27700320-27702132,
chr21:26848727-26851343~~chr21:27700565-27702018,
chr21:26848729-26851350~~chr21:27700318-27702132,
chr21:26848733-26851211~~chr21:27700246-27702059,
chr21:26848735-26851318~~chr21:27564094-27565665,
chr21:26848735-26851318~~chr21:27700350-27702114,
chr21:26848735-26852148~~chr21:27700351-27702121,
chr21:26848739-26851655~~chr21:27563988-27566020,
chr21:26848739-26851655~~chr21:27700076-27702211,
chr21:26848745-26851720~~chr21:27700358-27702051,
chr21:26848748-26851651~~chr21:27563895-27566084,
chr21:26848748-26851651~~chr21:27699952-27702148,
chr21:26848749-26851118~~chr21:27700496-27701999,
chr21:26848750-26851648~~chr21:27700517-27702048,
chr21:26848751-26851646~~chr21:27563920-27566182,
chr21:26848751-26851646~~chr21:27700023-27702186,
chr21:26848757-26851632~~chr21:27563925-27566163,
chr21:26848757-26851632~~chr21:27700291-27702152,
chr21:26848761-26852116~~chr21:27465346-27467252,
chr21:26848761-26852116~~chr21:27700300-27702127,
chr21:26848763-26851113~~chr21:27700525-27701999,
chr21:26848765-26851527~~chr21:27699929-27702131,
chr21:26848765-26851527~~chr21:27802176-27803976,
chr21:26848770-26851390~~chr21:27564032-27565789,
chr21:26848770-26851390~~chr21:27699952-27702098,
chr21:26848770-26851390~~chr21:27802290-27803924,
chr21:26848785-26851026~~chr21:27564188-27565622,
chr21:26848785-26851026~~chr21:27700507-27702020,
chr21:26848803-26851219~~chr21:27700394-27702179,
chr21:26848804-26851538~~chr21:27700287-27702107,
chr21:26848830-26851638~~chr21:27700281-27702128,
chr21:26848834-26851460~~chr21:27563907-27565665,
chr21:26848834-26851460~~chr21:27700290-27702123,
chr21:26848856-26851244~~chr21:27700305-27702116,
chr21:26848864-26851333~~chr21:27700333-27701995,
chr21:26848867-26851805~~chr21:27700506-27702101,
chr21:26848882-26851252~~chr21:27700303-27702035,
chr21:26848931-26851381~~chr21:27700288-27701996,
chr21:26848935-26851041~~chr21:27700220-27701917,
chr21:26848935-26851073~~chr21:27700474-27701901,
chr21:26848936-26851071~~chr21:27700526-27701775,
chr21:26848936-26851075~~chr21:27564009-27565590,
chr21:26848936-26851075~~chr21:27700042-27701914,
chr21:26848947-26851347~~chr21:27564022-27565633,
chr21:26848947-26851347~~chr21:27700028-27702259,
chr21:26848947-26851347~~chr21:27802087-27803810,
chr21:26848955-26851551~~chr21:27699963-27702208,
chr21:26848955-26851551~~chr21:27758404-27760678,
chr21:26848956-26852143~~chr21:27700277-27702128,
chr21:26848956-26852143~~chr21:27802108-27803785,
chr21:26848960-26851060~~chr21:27700563-27701854,
chr21:26849043-26851569~~chr21:27564132-27565614,
chr21:26849043-26851569~~chr21:27700335-27702088,
chr21:26849043-26851569~~chr21:27758641-27759952,
chr21:26849049-26852110~~chr21:27564063-27565789,
chr21:26849049-26852110~~chr21:27699913-27702170,
chr21:26849049-26852110~~chr21:27758357-27760293,
chr21:26849232-26851602~~chr21:27700517-27701777,
chr21:26849251-26851658~~chr21:27699991-27702131,
chr21:26849441-26851499~~chr21:27700289-27702138,
chr21:26849452-26851114~~chr21:27700473-27702088,
chr21:26849486-26851137~~chr21:27700482-27702087,
chr21:26849487-26851382~~chr21:27700376-27702045,
chr21:26849494-26851554~~chr21:27700337-27702131,
chr21:26849499-26851723~~chr21:27700510-27702123,
chr21:26850000-26875000~~chr21:26950000-26975000,
chr21:26850000-26875000~~chr21:27025000-27050000,
chr21:26850000-26875000~~chr21:27075000-27100000,
chr21:26850000-26875000~~chr21:27175000-27200000,
chr21:26850000-26875000~~chr21:27200000-27225000,
chr21:26850000-26875000~~chr21:27225000-27250000,
chr21:26850000-26875000~~chr21:27300000-27325000,
chr21:26850000-26875000~~chr21:27350000-27375000,
chr21:26850000-26875000~~chr21:27400000-27425000,
chr21:26850000-26875000~~chr21:27425000-27450000,
chr21:26850000-26875000~~chr21:27450000-27475000,
chr21:26850000-26875000~~chr21:27475000-27500000,
chr21:26850000-26875000~~chr21:27550000-27575000,
chr21:26850000-26875000~~chr21:27575000-27600000,
chr21:26850000-26875000~~chr21:27650000-27675000,
chr21:26850000-26875000~~chr21:27675000-27700000,
chr21:26850000-26875000~~chr21:27700000-27725000,
chr21:26850000-26875000~~chr21:28025000-28050000,
chr21:26850000-26875000~~chr21:28050000-28075000,
chr21:26850000-26875000~~chr21:28300000-28325000,
chr21:26850000-26875000~~chr21:28325000-28350000,
chr21:26850000-26875000~~chr21:28500000-28525000,
chr21:26850000-26875000~~chr21:28550000-28575000,
chr21:26850000-26875000~~chr21:28725000-28750000,
chr21:26850000-26875000~~chr21:28750000-28775000,
chr21:26850000-26875000~~chr21:28925000-28950000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIQYQWPF5, GSE95015, GSE43070, 4DNFIDJ2JZ7Q, 4DNFITUOMFUQ, ENCSR794RDS, 4DNFIBN9K4V9, ENCSR852KQC, ENCSR361AYD, GSE103148, 4DNFI7H4II2V, 4DNFIZ4F74QR, ENCSR350NJV, 4DNFIEYQ5ZIR, 4DNFIREVU1Z5, 4DNFIA6NSSBJ, ENCSR113OIR, 4DNFI9VXTBE2, 4DNFIKYXMF1E, 4DNFIRKGMZRQ, ENCSR668RDP, 4DNFIL5K3MA1, GSE97394, 4DNFICEGAHRC, 4DNFIE8T8JZ8, 4DNFI1E6NJQJ, 4DNFI9YAVTI1, 4DNFIJ5DQZVK, ENCSR658RQQ, ENCSR299VMZ, 4DNFI6XD6JAQ, 4DNFISPUVQHA, 4DNFIK61ILGM, GSE108869, GSE116872, 4DNFIAWVDQ8C, ENCSR305RTT, 4DNFI7XAZNNQ, ENCSR527RXH, GSE105028, ENCSR833CMG, 4DNFIBKZK63V, ENCSR033GUP, 4DNFIQWD8ZYD, GSE87112, 4DNFI3CFMRID, ENCSR662QKG, GSE94872, GSE118716, ENCSR499RVD, 4DNFIB7QTIMH, ENCSR146FPM, ENCSR478BMT, GSE69643, GSE155380, 4DNFIJWBWE41, 4DNFICSTCJQZ, ENCSR587DSF, 4DNFIIMZB6Y9, ENCSR452NHL, GSE80820, GSE52457, 4DNFIBT4EAKN, Direct, ENCSR314HAC, 4DNFIAS8LV1C, 4DNFIX7H3CE2, 4DNFIYIAUEPW, ENCSR244BBG, ENCSR991JXX, 4DNFI9815EEJ, ENCSR778FXH, 4DNFI9ZWZ5BS, 4DNFI2J1ODWB, 4DNFIVJ3IIQL, 4DNFIQ2687RT, 4DNFIFLJLIS5, 4DNFIDBIEXI7, 4DNFIDZT7PR8, 4DNFIS5F6EBL, 4DNFIH7TH4MF, 4DNFIT96Z365, 4DNFIWZEN3FF, ENCSR194SRI, 4DNFIR8OU6QJ, 4DNFI6CWNUFL, 4DNFI5CGQ46V, 4DNFIE8E4ANZ, GSE120294, GSE84022, ENCSR672RHL, 4DNFIW8TIFI5, ENCSR410MDC, 4DNFIMEG1QIC, ENCSR732QOH, 4DNFIBM714BP, 4DNFIF2D3TL9, 4DNFIFHU75I5, 4DNFIYD8LO9Z, ENCSR444BAR, ENCSR123UVP, 4DNFIL9M97T2, 4DNFIJBJ6QVH, ENCSR550JLK, 4DNFI3A3VYWU, 4DNFIM2BMJ33, GSE165038, 4DNFIALNLR78, 4DNFIBY3UHJB, 4DNFIYDBBSE3, ENCSR386KHY, ENCSR379CII, 4DNFIEJEFCAM, ENCSR393LOP, 4DNFIPAF4PYT, ENCSR255XYX, ENCSR404HWQ, 4DNFIE5TEYK7, 4DNFIJ8JKKWJ, 4DNFIFI6NIKJ, 4DNFIDKJFK2S, ENCSR933UZH, ENCSR094EIC, GSE116869, 4DNFI8649RQJ, 4DNFIRZA6EV6, GSE116875, 4DNFIMROE6N4, GSE108787, 4DNFI5SUHCGZ, ENCSR545YBD, 4DNFIILDWK8M, 4DNFIP25GZGA, 4DNFI6EIFUZI, ENCSR866FWQ, 4DNFII6AN691, GSE111537, GSE131580, ENCSR381DCY, ENCSR981FNA, 4DNFIV239W4L, GSE68977, ENCSR752QCX, 4DNFIOUSETUP, ENCSR128RPG, 4DNFISTWNV9C, 4DNFI6JJQKFJ, 4DNFI1UEG1HD, GSE101921, ENCSR228TUX, 4DNFI8JFOAJT, 4DNFIOCW5AEM, 4DNFIC3HAU11, 4DNFIQVMVRP6, ENCSR247RGI, ENCSR110JOO, ENCSR338WUS, 4DNFI5LCW273, 4DNFIP71EWXC, 4DNFINEQY95T, 4DNFIHN2QSMX, 4DNFII84FBKM, 4DNFIVSCH2CH
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
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Involved cell types for DEG evidence: SLK,OCI-AML-3,K-562,MCF-10A,U2OS,HeLa-S3,Keratinocytes
- Cohesin-DEGs, number of studies: 9
- Cohesin-DEGs, study: GSE83870,GSE111537,GSE101921,GSE138937,GSE131448,GSE89799,GSE130558
- Cohesin-DEGs, subunit: SA2,WAPL,CTCF,SMC1,Rad21