Deatailed information for cohesin site CDBP00415273

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  • Basic information
  • CohesinDB ID: CDBP00415273
  • Locus: chr21-25638808-25641127
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE126634, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE111537, GSE131606, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE115250, GSE86191, GSE93080, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE130135, GSE116344, GSE106870, GSE94872, GSE118494, GSE76815, GSE115248, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR167MTG, GSE131956, GSE111913, GSE155324, ENCSR054FKH, GSE83726, GSE50893
  • Cell type: RH4, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, TC-32, B-cell, H9-hESC, GM2630, RPE, Fibroblast, Ishikawa, Kelly, GM12890, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, HUES64, MCF-7, GM12892, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, OCI-AML-3, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 29% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.400
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 61% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "1_TssA": 20%, "2_TssAFlnk": 19%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, TRIM25, FOXA1, HLF, KDM3A, HDGF, THAP1, ZBTB44, IKZF3, PAX5, LMO2, OCA2, MED26, PITX3, ZNF561, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, ZNF263, TOP2A, STAT1, SAP130, ERG, ZBTB8A, NFKB2, EZH1, SMARCA4, RFX1, ZNF398, RCOR1, CEBPB, CREB1, GABPB1, ZHX2, KLF17, GATA2, MXD3, FLI1, HCFC1, MXI1, RELB, RUNX1, NKX2-2, REPIN1, TRIM22, SMARCC1, PRDM10, ZBTB2, CBX4, ZBTB10, ATF2, FOXM1, SP2, SMAD1, GSPT2, ARID2, NFATC3, MEF2B, ZNF207, CREM, CHD2, SS18, WT1, MEF2C, NEUROD1, ZFP36, BATF, MAF1, PLAG1, ZFP69B, BCL11B, MED, EGR2, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, FOSL1, ZNF660, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, ZNF467, INTS11, ELF1, RBM39, SNAI2, CTCF, ZBTB20, RYBP, DPF2, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, MTA2, ZBTB17, ZBTB48, SRF, NBN, ONECUT1, KDM4A, ZNF2, FOXP2, RXRA, PRDM14, VDR, NR3C1, KMT2A, ZBTB11, KLF8, GRHL2, EBF3, ZSCAN29, SMARCA5, NFIL3, EZH2phosphoT487, SOX13, POU4F2, ZNF513, SP3, ARNT, BACH1, ZNF48, ZEB2, NCAPH2, ZXDB, KLF9, USF1, SP1, BCL11A, ZNF479, ATF7, ASH2L, PCGF2, CTBP2, GLIS2, SMC3, MLLT1, STAG1, ZNF394, TRP47, AGO1, MTA3, EBF1, ZNF580, BCL3, KDM1A, ZNF222, BRG1, ZIC2, PCGF1, GATA3, TAL1, ZNF143, AGO2, CBX2, TP53, NFKB1, ZSCAN22, BRD2, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, TBX2, SOX2, PATZ1, RING1B, BMI1, CHD7, ZNF189, KLF6, SAP30, ESR1, KLF1, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, KDM4C, ZSCAN5A, ERG2, SP4, HIC1, TBP, OGG1, ETS1, MYC, KLF12, GABPA, STAT3, IKZF1, EZH2, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF777, ZNF76, ZNF554, ETV5, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, MEF2A, ZNF384, ZNF35, TAF15, SMAD4, CDK8, ZEB1, REST, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, TBL1X, ZNF692, GTF2B, ZNF574, ZNF823, RELA, TARDBP, MAX, ZNF223, NEUROG2, NR2F1, KDM5B, PKNOX1, MYOD1, AR, PAX3-FOXO1, YAP1, ZNF324, HEXIM1, AHR, HMG20A, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, ZNF362, CTCFL, PRDM1, MECOM, ZNF629, TRIM28, BCLAF1, ETV1, TCF12, EP300, PRDM4, E2F1, SMC1, TEAD4, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, GATAD1, ASCL1, USP7, ZNF341, RAD21, GRHL3, XRCC5, ZNF639, ARNTL, ZNF501, FEZF1, MRTFB, PTBP1, SMC1A, SIRT6, ZNF335, ZFX, SMAD3, NMYC, CBX8, TWIST1, RUNX2, ZSCAN30, OSR2, CHD1, FOS, MED1, KDM6B, MYB, SCRT2, L3MBTL2, SETDB1, KLF16, ZBTB7A, PHIP, TCF3, PAX7, SKI, FOXA2, RBBP5, E2F8, ZNF600, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, ZNF519, HAND2, SP7, NCOA3, ZNF512, ZNF843, BHLHE40, TAF1, ZBTB42, NOTCH3, MAZ
  • Target gene symbol (double-evidenced CRMs): JAM2,MRPL39,ATP5PF,APP,ADAMTS1,GABPA
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 69
  • Number of somatic mutations (non-coding): 26
  • Related genes and loops
  • Related gene: ENSG00000154719, ENSG00000154721, ENSG00000154723, ENSG00000154727, ENSG00000142192, ENSG00000154734,
  • Related loop: chr21:25606733-25609495~~chr21:25639158-25640825, chr21:25606735-25609548~~chr21:25638240-25641048, chr21:25606790-25609462~~chr21:25639349-25640533, chr21:25606798-25609451~~chr21:25639345-25640775, chr21:25606813-25609564~~chr21:25639067-25640965, chr21:25606899-25609820~~chr21:25639037-25640766, chr21:25625000-25650000~~chr21:25725000-25750000, chr21:25625000-25650000~~chr21:25775000-25800000, chr21:25625000-25650000~~chr21:26150000-26175000, chr21:25625000-25650000~~chr21:26825000-26850000, chr21:25625000-25650000~~chr21:28050000-28075000,
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