Deatailed information for gene ENSG00000154727
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00009793
- Gene Symbol: GABPA
- Ensembl ID: ENSG00000154727
-
Gene locus: chr21:25734569-25772460
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-25375559-25376065,
chr21-25383848-25387605,
chr21-25387847-25388717,
chr21-25395973-25396887,
chr21-25399514-25400754,
chr21-25401827-25402550,
chr21-25420705-25426209,
chr21-25572281-25575261,
chr21-25576227-25589346,
chr21-25589610-25591105,
chr21-25591791-25592728,
chr21-25595802-25596358,
chr21-25600851-25601124,
chr21-25606719-25610187,
chr21-25614176-25615182,
chr21-25624549-25624749,
chr21-25626132-25626377,
chr21-25626696-25627327,
chr21-25638808-25641127,
chr21-25642332-25642777,
chr21-25646355-25647152,
chr21-25647707-25648230,
chr21-25731829-25732870,
chr21-25733103-25733519,
chr21-25733724-25736727,
chr21-25750080-25750495,
chr21-25756342-25756628,
chr21-25770235-25770898,
chr21-25800560-25802279,
chr21-25850382-25850871,
chr21-25857068-25857674,
chr21-25862118-25863437,
chr21-25865445-25866261,
chr21-25866908-25867564,
chr21-25868924-25869531,
chr21-25871333-25873005,
chr21-25949635-25950151,
chr21-25952178-25952242,
chr21-25953149-25954885,
chr21-25957155-25957888,
chr21-25959897-25962359,
chr21-25962876-25964940,
chr21-25965954-25968091,
chr21-25969014-25969348,
chr21-25970446-25971016,
chr21-25972490-25972729,
chr21-26150217-26150652,
chr21-26151334-26152383,
chr21-26153595-26154542,
chr21-26154777-26155253,
chr21-26158881-26159268,
chr21-26159924-26160609,
chr21-26162072-26162427,
chr21-26162939-26163160,
chr21-26163946-26164899,
chr21-26165409-26165563,
chr21-26165938-26172090,
chr21-26172443-26173621,
chr21-26375270-26375569,
chr21-26377212-26377465,
chr21-26385630-26386225,
chr21-26388039-26392190,
chr21-26405129-26407108,
chr21-26408839-26409266,
chr21-26409616-26410188,
chr21-26411556-26411854,
chr21-26412621-26413492,
chr21-26447728-26450082,
chr21-26451013-26451552,
chr21-26451854-26451922,
chr21-26469516-26470634,
chr21-26470936-26471471,
chr21-26527113-26527235,
chr21-26529571-26529884,
chr21-26542226-26542363,
chr21-26543512-26543793,
chr21-26545511-26545777,
chr21-26546651-26547189,
chr21-26677932-26678184,
chr21-26681492-26681815,
chr21-26684363-26684507,
chr21-26686016-26686591,
chr21-26690085-26690451,
chr21-26698349-26698770,
chr21-26702109-26702704,
chr21-26709227-26709736,
chr21-26714761-26718662,
chr21-26718980-26720367,
chr21-26721013-26721255,
chr21-26721627-26722108,
chr21-26801063-26801912,
chr21-26805125-26805692,
chr21-26806617-26807296,
chr21-26810912-26811585,
chr21-26814123-26815116,
chr21-26815437-26816621,
chr21-26816961-26817766,
chr21-26819112-26820624,
chr21-26824624-26825033,
chr21-26826754-26827193,
chr21-26832682-26836085,
chr21-26836642-26836862,
chr21-26837135-26838300,
chr21-26839542-26841526,
chr21-26841743-26847812,
chr21-26848196-26852813,
-
Co-expression with cohesin genes Rho = 0.7692
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.273
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.874
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: H9-endodermal,IMR-90,MCF-10A,DU145,H1-Mesenchymal,Hepatocyte-H9,GM12878,MSiPS,K-562,HFFc6,PAEC,HeLa-S3,LNCaP,H9-hESC,Primed-hESC,ARPE-19,Hep-G2,Kelly,H1-hESC,HT-1376,Motor-Neuron,NaiveB,SU-DHL-4,NPC-H9,RT-112,Skin-Fibroblast,HFF-hTERT,HAP1
- Related loop:
chr21:17600000-17625000~~chr21:25725000-25750000,
chr21:17775000-17800000~~chr21:25725000-25750000,
chr21:25375000-25400000~~chr21:25725000-25750000,
chr21:25400000-25425000~~chr21:25725000-25750000,
chr21:25400000-25425000~~chr21:25775000-25800000,
chr21:25575000-25600000~~chr21:25750000-25775000,
chr21:25600000-25625000~~chr21:25725000-25750000,
chr21:25600000-25625000~~chr21:25750000-25775000,
chr21:25606634-25609370~~chr21:25734065-25736120,
chr21:25606735-25609548~~chr21:25733753-25735837,
chr21:25606776-25609578~~chr21:25734027-25737101,
chr21:25606787-25609495~~chr21:25734193-25735774,
chr21:25606798-25609451~~chr21:25733716-25736049,
chr21:25606803-25609752~~chr21:25733690-25736009,
chr21:25606813-25609514~~chr21:25734223-25736000,
chr21:25606813-25609539~~chr21:25734172-25735871,
chr21:25606813-25609564~~chr21:25734147-25737065,
chr21:25606818-25609406~~chr21:25734212-25736761,
chr21:25606832-25609355~~chr21:25734228-25736011,
chr21:25606834-25609470~~chr21:25733847-25735307,
chr21:25606843-25609485~~chr21:25733632-25735523,
chr21:25606889-25609464~~chr21:25734236-25735414,
chr21:25606920-25609321~~chr21:25734731-25735901,
chr21:25625000-25650000~~chr21:25725000-25750000,
chr21:25625000-25650000~~chr21:25775000-25800000,
chr21:25725000-25750000~~chr21:26825000-26850000,
chr21:25725000-25750000~~chr21:28750000-28775000,
chr21:25725000-25750000~~chr21:28975000-29000000,
chr21:25725000-25750000~~chr21:29000000-29025000,
chr21:25725000-25750000~~chr21:32600000-32625000,
chr21:25725000-25750000~~chr21:39175000-39200000,
chr21:25733508-25737031~~chr21:25800793-25802413,
chr21:25734147-25737065~~chr21:26715239-26718238,
chr21:25750000-25775000~~chr21:25850000-25875000,
chr21:25750000-25775000~~chr21:25950000-25975000,
chr21:25750000-25775000~~chr21:26150000-26175000,
chr21:25750000-25775000~~chr21:26400000-26425000,
chr21:25750000-25775000~~chr21:26450000-26475000,
chr21:25750000-25775000~~chr21:26525000-26550000,
chr21:25750000-25775000~~chr21:29050000-29075000,
chr21:25775000-25800000~~chr21:25950000-25975000,
chr21:25775000-25800000~~chr21:26150000-26175000,
chr21:25775000-25800000~~chr21:26375000-26400000,
chr21:25775000-25800000~~chr21:26525000-26550000,
chr21:25775000-25800000~~chr21:26675000-26700000,
chr21:25775000-25800000~~chr21:26700000-26725000,
chr21:25775000-25800000~~chr21:26800000-26825000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFI8649RQJ, 4DNFI3CFMRID, GSE95015, 4DNFIWZEN3FF, ENCSR194SRI, 4DNFIDJ2JZ7Q, 4DNFIMROE6N4, 4DNFITUOMFUQ, 4DNFIE8E4ANZ, ENCSR794RDS, 4DNFI5SUHCGZ, ENCSR545YBD, ENCSR852KQC, GSE84022, GSE120294, ENCSR672RHL, GSE103148, 4DNFI7H4II2V, 4DNFIW8TIFI5, ENCSR410MDC, ENCSR350NJV, ENCSR478BMT, ENCSR732QOH, ENCSR113OIR, GSE69643, ENCSR668RDP, ENCSR381DCY, GSE155380, 4DNFICSTCJQZ, ENCSR981FNA, 4DNFIV239W4L, ENCSR587DSF, GSE80820, 4DNFIE8T8JZ8, 4DNFI9YAVTI1, 4DNFIBT4EAKN, GSE52457, 4DNFI3A3VYWU, ENCSR658RQQ, 4DNFIX4PJKXZ, Direct, 4DNFISPUVQHA, 4DNFI1UEG1HD, GSE101921, GSE108869, 4DNFIEJEFCAM, ENCSR778FXH, 4DNFIQVMVRP6, 4DNFI9ZWZ5BS, ENCSR247RGI, ENCSR110JOO, 4DNFIVJ3IIQL, ENCSR933UZH, GSE105028, 4DNFIDBIEXI7, 4DNFIDZT7PR8, 4DNFIZGCA8AH, 4DNFIH7TH4MF, 4DNFII84FBKM
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: MCF-7,CMK,U2OS,HeLa-S3,Keratinocytes
- Cohesin-DEGs, number of studies: 6
- Cohesin-DEGs, study: GSE83870,GSE177045,GSE154086,GSE89799,GSE130558
- Cohesin-DEGs, subunit: WAPL,SMC1,Rad21,SA2