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Basic information

CohesinDB ID: CDBP00415355

Locus: chr21-25952178-25952242

Data sourse: GSE120943, GSE98367

Cell type: Monocytes, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 65%, "4_Tx": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, SOX2, NME2, XBP1, FOXA1, MLL4, TFAP4, ATF3, ZSCAN4, TP63, ZNF736, CDX2, TEAD1, ZNF573, KLF6, SNAI2, ESR1, HNF1B, OCA2, MLL, JUN, CTCF, SMC1, TEAD4, PDX1, CHD8, TOP2A, ZNF317, DUX4, ERG, HOXC5, MYC, SMARCA4, RAD21, LHX2, GRHL3, PROX1, STAT3, NR3C1, CEBPB, CREB1, GRHL2, SPI1, IRF1, GATA2, ZNF766, RUNX1, CTNNB1, SMC1A, LDB1, SMAD3, ZNF384, RUNX2, PBX4, ARNT, DAXX, PBX3, FOS, CDK8, MED1, ZEB1, CEBPD, MYB, NCOA1, RBM22, USF1, BCL11A, NIPBL, SP1, ZNF605, FOXP1, FOXA2, CBX3, PAF1, GTF2B, HOXB13, ZNF19, RELA, YY1, JUNB, GATA3, TAL1, MAX, ZNF143, AGO2, KLF4, TCF7L2, TP53, PKNOX1, PHOX2B, ELF3, AR, PAX3-FOXO1, NOTCH3, BRD4, JUND, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): APP,CYYR1,GABPA

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000154727, ENSG00000142192, ENSG00000166265,

eachgene

Deatailed information for cohesin site CDBP00415355