- Basic information
- CohesinDB ID: CDBP00415359
- Locus: chr21-25962876-25964940
-
Data sourse: ENCSR000BTU, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE67783, GSE98367, ENCSR000BSB, GSE129526, GSE111913, ENCSR000BLY, GSE94872, GSE206145, GSE101921, ENCSR000EDE, GSE68388, GSE138105, GSE108869, GSE126755, ENCSR000ECS, ENCSR917QNE
-
Cell type: MCF-7, Macrophage, RPE, HCT-116, SLK, Ishikawa, HUVEC, HCAEC, HeLa-S3, SK-N-SH, RT-112, Liver, Neutrophil, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 7% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.833
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 60%,
"7_Enh": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOSL1, PGR, SOX2, XBP1, FOXA1, TFAP4, ATF3, NFIC, ZFP64, CHD7, ZNF467, CDX2, MYOG, TEAD1, KLF6, SNAI2, SAP30, ESR1, HNF1B, JUN, TCF12, CTCF, EP300, BAF155, GATA6, DPF2, SOX4, IRF4, E2F1, SMC1, TEAD4, ZNF175, PDX1, TFAP2C, GLIS1, NANOG, CHD8, POU5F1, CTBP1, ZBTB48, STAT1, SRF, MLLT3, DDX5, ERG, HOXC5, PBX1, OGG1, ETS1, MYC, SMARCA4, RAD21, RXRA, NKX2-1, PROX1, GABPA, STAT3, NKX3-1, RCOR1, ZNF750, CEBPB, ESRRA, NR3C1, KMT2A, CREB1, FEZF1, GRHL2, EBF3, ZHX2, SPI1, EHF, IRF1, HDAC2, GATA2, FLI1, MRTFB, NCOA2, RUNX1, SMC1A, NKX2-2, SIN3A, ZFX, SMAD3, ZNF770, SMARCC1, CREBBP, ZNF384, RUNX2, SMAD2, PBX4, DAXX, NRF1, ATF2, PBX3, FOXM1, FOS, CDK8, MED1, SPDEF, PIAS1, NR1H2, RBM22, MAFK, NIPBL, SP1, BCL11A, REST, ASH2L, CTBP2, PHIP, BCOR, FOXP1, TCF3, PRDM6, SMC3, STAG2, STAG1, CBX3, FOXA2, ESR2, CDK9, HOXB13, KDM1A, YY1, RELA, NEUROD1, JUNB, ISL1, HIF1A, PCGF1, OTX2, GATA3, TAL1, MAX, NRIP1, HAND2, KLF4, NR2F2, TCF7L2, KDM5B, TP53, NFKB1, MYOD1, PHOX2B, ELF3, AR, TAF1, EGLN2, BRD4, JUND, TBX2, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): GABPA,APP,CYYR1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 144
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000154727,
ENSG00000142192,
ENSG00000166265,
- Related loop:
chr21:25750000-25775000~~chr21:25950000-25975000,
chr21:25775000-25800000~~chr21:25950000-25975000,
chr21:25924913-25927132~~chr21:25962734-25964839,
chr21:25950000-25975000~~chr21:26050000-26075000,
chr21:25950000-25975000~~chr21:26075000-26100000,
chr21:25950000-25975000~~chr21:26125000-26150000,
chr21:25950000-25975000~~chr21:26150000-26175000,
chr21:25950000-25975000~~chr21:26250000-26275000,
chr21:25950000-25975000~~chr21:26375000-26400000,
chr21:25950000-25975000~~chr21:26525000-26550000,
chr21:25950000-25975000~~chr21:26800000-26825000,