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Basic information

CohesinDB ID: CDBP00415295

Locus: chr21-25733103-25733519

Data sourse: GSE206145-GSE177045, GSE67783, GSE126634, GSE206145-NatGen2015, ENCSR153HNT

Cell type: MCF-7, Fibroblast, HSPC, K-562, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: Mau2,SA1,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 61% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 29%, "7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, SFPQ, TEAD1, ZNF121, SNAPC1, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, E4F1, ARID5B, ZNF75A, SOX5, ZNF407, DEK, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, ZNF263, BRD3, TOP2A, POU5F1, CTBP1, ZMYND11, ERF, DUX4, STAT1, SAP130, ERG, PAX6, ZBTB21, ZBTB8A, EZH1, SMARCA4, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, CD74, CEBPB, HNRNPL, CREB1, DDX21, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, NR2C2, RELB, EP400, RUVBL2, RUNX1, CEBPA, NKX2-2, HDAC1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ELK1, ZBTB10, ATF2, SNIP1, FOXM1, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, GSPT2, ARID2, IKZF5, OVOL3, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, ILF3, ZNF316, ZNF660, XBP1, KDM4B, ZNF101, PBX2, HNRNPK, ATF3, THRB, ZC3H8, ZFP64, RUNX3, CBFB, ZNF273, TP63, ZSCAN4, MITF, ZNF467, ZNF780A, JMJD1C, MAF, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, L3MBTL4, MNT, LMO1, ZBTB20, DPF2, RYBP, SIX5, IRF4, DDX20, ZNF423, ZNF350, ZNF280A, PDX1, TFAP2C, MLX, RBPJ, MTA2, ZSCAN21, ZNF317, ZBTB17, ZBTB48, NONO, SRF, DDX5, NBN, PBX1, ONECUT1, ZNF2, HOMEZ, FOXP2, KDM4A, RXRA, NKX3-1, PRDM14, LEF1, MIER3, HNRNPH1, TEAD2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, FOXK1, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, SSRP1, ZNF146, ZSCAN29, NFIL3, THAP11, CTNNB1, ZNF585A, ZBTB24, EZH2phosphoT487, LDB1, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, CEBPZ, SP3, ARNT, NFIB, BACH1, ZNF48, HMBOX1, ZEB2, NFYA, ETV6, NCAPH2, ZNF10, PBX3, HMGXB4, MAFB, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, SP1, BCL11A, NKX2-5, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, MLLT1, STAG1, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF441, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, SPIN1, CUX1, ZSCAN23, TBX2, ZFP42, ZNF468, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, TFAP4, SIN3B, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, SND1, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ASH1L, ZSCAN5A, ELK4, ERG2, SP4, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ZNF671, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, TAF9B, ZNF490, ZNF76, NCOA2, ETV5, BCL6, SIN3A, ZFP37, ERG3, MEF2A, RARA, ZNF384, NFYC, CREBBP, TAF15, ZNF35, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, SPDEF, SUPT16H, NCOA1, SREBF2, ZNF22, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, JDP2, ZNF574, TCF7, YY2, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, RUVBL1, AR, KMT2D, PAX3-FOXO1, YAP1, ZNF324, HEXIM1, AHR, DMAP1, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, SOX6, CREB3, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, MLLT3, GATAD1, GMEB2, ARID3A, MIER1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, ZNF501, FEZF1, TRPS1, TFE3, HBP1, EHF, IRF1, SREBF1, ZGPAT, NAB2, MRTFB, ZIM3, ZC3H11A, MYF5, ATF1, PTBP1, ZNF45A, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZSCAN30, NRF1, PBX4, NR2C1, SUPT5H, CHD1, FOS, TGIF2, MED1, CEBPD, KDM6B, SCRT2, MYB, ZNF558, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, NELFA, ZNF283, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF740, GATA1, HAND2, CEBPG, SP7, NR2F2, ZNF512, ZNF687, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ETS2, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, MEF2D, ZNF24

Target gene symbol (double-evidenced CRMs): ATP5PF,GABPA,JAM2,MRPL39,ADAMTS1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 7

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154721, ENSG00000154723, ENSG00000154727, ENSG00000154734,

eachgene

Deatailed information for cohesin site CDBP00415295