Deatailed information for cohesin site CDBP00415569

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  • Basic information
  • CohesinDB ID: CDBP00415569
  • Locus: chr21-26815437-26816621
  • Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, GSE126634, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE93080, GSE122299, GSE138405, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE138105, GSE130135, ENCSR703TNG, GSE116344, GSE94872, GSE98367, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, GSE206145, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR000BTQ, GSE105004, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR000EDE, GSE68388, GSE126990, GSE50893, ENCSR000ECS
  • Cell type: MDM, RH4, SLK, Liver, HuCC-T1, H9-hESC, RPE, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, DKO, H1-hESC, Monocytes, GM12878, GM12891, GBM39, SK-N-SH, RT-112, THP-1, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, HeLa, HAP1
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 23% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.589
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 41% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 72%, "7_Enh": 13%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, ZNF391, ZSCAN5C, SOX2, NME2, XBP1, FOXA1, SUZ12, ZNF274, NFIC, CTCFL, ZBTB44, CHD7, ZNF444, ZSCAN4, TRIM28, SNAI2, ESR1, ZNF561, CTCF, JUN, EP300, BAF155, PAX8, ZNF410, ZNF528, SMC1, TEAD4, PDX1, GLIS1, NANOG, POU5F1, MYCN, RUNX1T1, ZSCAN21, ZSCAN5A, STAT1, SRF, DDX5, ERG, MYC, SMARCA4, RFX1, TSHZ1, RAD21, ZNF2, GRHL3, RXRA, NKX2-1, GABPA, STAT3, UBN1, NKX3-1, NFE2, ZNF639, NR3C1, CEBPB, CREB1, KLF8, ZHX2, ZNF664, GATA2, FLI1, MRTFB, SMC1A, CBX1, NKX2-2, SMAD3, REPIN1, ZFP37, ZNF770, ZNF654, TRIM22, SMARCC1, ZNF18, PRDM10, ZBTB2, ZNF35, GATA4, OSR2, PBX4, NRF1, ZEB2, MAFB, ZNF10, MED1, ZEB1, ZXDB, SCRT2, PIAS1, NUP98-HOXA9, SP1, HNF4A, REST, ZHX1, HOXA9, PHIP, FOXP1, PRDM6, SMC3, ZNF34, STAG1, FOXA2, SS18, ZNF692, ZSCAN16, MAFF, FOXF1, HOXB13, KDM1A, YY1, NEUROD1, BRG1, HIF1A, OTX2, MAX, TLE3, KLF4, BCL11B, SP7, TP53, ZNF334, PHOX2B, T, BRD2, AR, ZNF324, EGLN2, ZBTB42, ZNF280D, HSF1, NCOR1, BRD4, SCRT1, ZSCAN23, BRCA1
  • Target gene symbol (double-evidenced CRMs): MRPL39,APP,GABPA
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 16
  • Related genes and loops
  • Related gene: ENSG00000154719, ENSG00000154727, ENSG00000142192,
  • Related loop: chr21:25300000-25325000~~chr21:26800000-26825000, chr21:25575000-25600000~~chr21:26800000-26825000, chr21:25775000-25800000~~chr21:26800000-26825000, chr21:25950000-25975000~~chr21:26800000-26825000, chr21:26150000-26175000~~chr21:26800000-26825000, chr21:26375000-26400000~~chr21:26800000-26825000, chr21:26800000-26825000~~chr21:28225000-28250000, chr21:26800000-26825000~~chr21:28725000-28750000, chr21:26800000-26825000~~chr21:28950000-28975000, chr21:26815238-26816923~~chr21:27700282-27702347,
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