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Basic information

CohesinDB ID: CDBP00415262

Locus: chr21-25572281-25575261

Data sourse: GSE104888, GSE72082, GSE126634, ENCSR000BLY, ENCSR404BPV, GSE103477, GSE25021, GSE165895, ENCSR000EFJ, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE138105, ENCSR703TNG, ENCSR895JMI, ENCSR879KXD, GSE206145, GSE85526, GSE62063, ENCSR000BMY, ENCSR000EHX, GSE129526, ENCSR000HPG, GSE155324, ENCSR000EDE, GSE68388, GSE50893

Cell type: MDM, GM10847, SLK, HuCC-T1, B-cell, RPE, HMEC, Fibroblast, HEKn, HeLa-S3, GM2255, IMR-90, K-562, HFFc6, GM18526, GM18951, SNYDER, Monocytes, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, Ramos, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Neurons-H1, A-549, HCAEC, GM19238, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 18% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.611

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 61% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 44%, "7_Enh": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, NME2, FOXA1, HDGF, MEN1, SRSF7, MORC2, PAX5, TEAD1, LMO2, OCA2, ARID5B, PAX8, ZNF528, KMT2B, JARID2, NANOG, ZNF263, BRD3, TOP2A, POU5F1, CTBP1, ERF, STAT1, ERG, PAX6, ZNF597, NFKB2, SMARCA4, RFX1, RCOR1, CD74, DACH1, CEBPB, CREB1, EPAS1, BMPR1A, ZHX2, MIXL1, GATA2, SIX2, FLI1, HCFC1, DRAP1, MXI1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, TRIM22, SMARCC1, PRDM10, ZBTB2, SOX11, TFDP1, ATF2, FOXM1, PML, TERF1, PIAS1, SMAD1, EVI1, STAT5A, GSPT2, ARID2, NFATC3, MEF2B, ZNF207, CREM, NFATC1, PAF1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZFP36, TCF4, BATF, MAF1, SPIB, KLF4, BCL11B, MED, EGR2, ELF3, RXR, ZNF366, HSF1, NCOR1, ZNF316, FOSL1, SMARCA2, ZNF660, XBP1, HNF1A, PBX2, HNRNPK, TSC22D4, THRB, ATF3, ZFP64, RUNX3, CBFB, TP63, MITF, BACH2, JMJD1C, MAF, INTS11, ELF1, SNAI2, SMAD5, CTCF, JUN, MNT, LMO1, RYBP, DPF2, SIX5, IRF4, PDX1, TFAP2C, RBPJ, MTA2, ZSCAN21, ZBTB48, ZBTB17, ZNF317, SRF, DDX5, NBN, PBX1, KDM4A, HOMEZ, FOXP2, LHX2, RXRA, BATF3, NKX3-1, PRDM14, VDR, NR3C1, ESRRA, STAT5B, KMT2A, KLF8, GRHL2, EBF3, SMARCA5, EZH2phosphoT487, AFF4, POU4F2, ZNF18, CEBPZ, ARNT, BACH1, PRDM9, HMBOX1, ZEB2, ETV6, PBX3, NCAPH2, KLF9, USF1, BCL11A, SP1, ATF7, ASH2L, CTBP2, PRDM6, SMC3, STAT2, MLLT1, STAG2, STAG1, ZNF394, TRP47, MTA3, EBF1, MEIS1, MAFF, BCL3, KDM1A, BRG1, ISL1, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF334, NFKB1, ZSCAN22, BRD2, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, CBX5, PGR, ZNF496, SOX2, LEO1, RING1B, TFAP4, BMI1, CHD7, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SND1, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, KDM4C, HIC1, ERG2, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, EZH2, MRTFA, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, NCOA2, ETV5, BCL6, SIN3A, ERG3, MEF2A, CREBBP, RARA, ZNF384, ZNF35, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, MAFK, NR4A1, HNF4A, REST, ARID1A, HOXA9, BCOR, FOXP1, AATF, NCOR2, HDAC6, GTF2B, ZNF574, TCF7, RELA, TARDBP, SKIL, MAX, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, AR, ZNF324, HEXIM1, AHR, FOSL2, E2F7, MEIS2, SUZ12, ZFHX2, NFIC, ZNF362, CTCFL, PRDM1, MECOM, HDAC3, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, MLL, HNF1B, USF2, TCF12, EP300, BAF155, SOX6, RAD51, E2F1, SMC1, TEAD4, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, MLLT3, ARID3A, RAD21, GRHL3, PROX1, NFE2, ZNF639, ZNF664, IRF1, MRTFB, SMC1A, MAFG, SIRT6, ZFX, ZNF534, SMAD3, TWIST1, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, PBX4, FOS, CHD1, SUPT5H, MED1, CEBPD, MYB, KDM6B, SCRT2, SETDB1, HIF2A, NIPBL, PHIP, TCF3, SKI, ZNF283, FOXA2, RBBP5, E2F8, ZBED1, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, BHLHE22, GATA1, HAND2, TLE3, CEBPG, SP7, NR2F2, ZNF687, BHLHE40, TAF1, ZBTB40, NOTCH3, MAZ, ZNF440, ZNF24

Target gene symbol (double-evidenced CRMs): ATP5PF,GABPA,APP,JAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 26

Related genes and loops

Related gene: ENSG00000154721, ENSG00000154723, ENSG00000154727, ENSG00000142192,

eachgene

Deatailed information for cohesin site CDBP00415262