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Basic information

CohesinDB ID: CDBP00415575

Locus: chr21-26836642-26836862

Data sourse: GSE116344, ENCSR000ECS

Cell type: HeLa-S3, RH4

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SMC3,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 41% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 32%, "4_Tx": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, KDM3A, ZBTB44, IKZF3, MORC2, ZNF320, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, ZNF561, ZNF577, ARID5B, DEK, E2F4, ZNF528, KLF3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, BRD3, TOP2A, POU5F1, ERF, ZMYND11, DUX4, STAT1, ZNF134, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, RFX1, TOP1, UBN1, ZNF398, RCOR1, DACH1, CEBPB, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, KLF17, ZNF257, GATA2, MXD3, FLI1, HCFC1, MXI1, DRAP1, RUNX1, CEBPA, NKX2-2, HDAC1, CRY1, REPIN1, ZNF654, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, TFDP1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, PIAS1, SMAD1, NR1H2, GSPT2, ARID2, IKZF5, ELL2, NFATC3, CHD2, SS18, NFATC1, ZSCAN16, WT1, MPHOSPH8, JUNB, NEUROD1, ZFP36, KLF4, ZFP69B, BCL11B, ZNF281, ZBTB6, MED, EGR2, ELF3, RXR, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, FOSL1, ZNF660, XBP1, ZNF101, ZNF596, HNRNPK, ATF3, ZFP64, CBFB, DPF1, TP63, ZSCAN4, MITF, ZNF467, MAF, INTS11, MYOG, ELF1, RBM39, SNAI2, KLF10, ZNF624, ZNF571, FUS, CTCF, JUN, MNT, LMO1, ZBTB20, RYBP, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, ZNF239, ZNF317, ZBTB17, ZBTB48, ZSCAN21, SRF, PBX1, ONECUT1, TSHZ1, ZNF2, FOXP2, KDM4A, RXRA, NKX3-1, PRDM14, VDR, NR3C1, STAT5B, KMT2A, ZBTB11, KLF8, GRHL2, EBF3, ZBTB14, SSRP1, NFIL3, CIITA, EZH2phosphoT487, AFF4, SOX13, POU4F2, ZNF770, ZNF513, ZNF18, SP3, NFIB, DAXX, ARNT, BACH1, ZNF48, PRDM9, ZEB2, PBX3, NCAPH2, ZNF10, MAFB, HMGXB4, TEAD3, ZXDB, TAF7, KLF9, TBX5, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, ZNF623, SMC3, STAG1, STAG2, ZNF394, TRP47, AGO1, EBF1, MAFF, ZNF580, ZKSCAN1, KLF7, KDM1A, ZNF222, KAT2B, BRG1, ZNF830, ZIC2, PCGF1, GATA3, TAL1, ZNF143, AGO2, MTA1, ZNF768, TP53, ZNF645, NFKB1, ZSCAN22, PHOX2B, BRD2, TBX21, EGR1, TFIIIC, RNF2, BRD4, JUND, SPIN1, CUX1, ZSCAN23, TBX2, ZNF468, PGR, ZNF496, SOX2, PATZ1, RING1B, LEO1, BMI1, CHD7, ATF4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ESR1, TP73, ZNF524, KLF1, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ZMYND8, HIC1, ERG2, SP4, TBP, HOXC5, OGG1, ETS1, MYC, NKX2-1, GABPA, STAT3, INO80, EZH2, ZNF652, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, INTS13, ZNF777, ZNF76, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, CREBBP, ZNF35, ZNF384, RARA, TAF15, HMGB2, ZNF518A, SMAD4, CDK8, CSNK2A1, ZEB1, SPDEF, ZNF879, SUPT16H, NCOA1, SREBF2, ZNF22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, ZNF543, BCOR, FOXP1, AATF, ZNF34, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF574, YY2, RELA, TARDBP, CHAMP1, MAX, ZNF223, GFI1B, TCF7L2, KDM5B, PKNOX1, ZNF547, MYOD1, T, AR, YAP1, ZNF324, HEXIM1, AHR, FOSL2, MBD3, ZNF391, E2F7, ZSCAN5C, SUZ12, RBFOX2, ZFHX2, SFMBT1, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, HDAC3, ZNF629, ZNF506, KLF5, TRIM28, ETV1, HNF1B, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, ZNF425, CHD8, BRD1, MYCN, CDK7, RUNX1T1, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, XRCC5, NFE2, ZNF639, ARNTL, ZNF501, ZNF750, FEZF1, ZNF664, EHF, IRF1, MRTFB, ZIM3, MYF5, PTBP1, SMC1A, SIRT6, ZNF335, ZFX, NFKBIA, ZNF534, SMAD3, NMYC, TWIST1, NOTCH1, RUNX2, ZSCAN30, CDK6, OSR2, ZNF184, GATA4, GR, PBX4, NRF1, SMAD2, FOS, CHD1, SUPT5H, MED1, CEBPD, MYB, SCRT2, ZNF558, KDM6B, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, PHIP, TCF3, SKI, NELFA, ZNF283, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF213, ZNF837, ZNF843, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, NOTCH3, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): JAM2,GABPA,APP,ATP5PF,ADAMTS1,MRPL39,ADAMTS5,LINC00113

Function elements

Human SNPs: .

Number of somatic mutations (coding): 1

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154721, ENSG00000154723, ENSG00000154727, ENSG00000142192, ENSG00000154734, ENSG00000154736, ENSG00000225298,

eachgene

Deatailed information for cohesin site CDBP00415575