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Basic information

CohesinDB ID: CDBP00415306

Locus: chr21-25800560-25802279

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, T-47D, A-549, HUVEC, HCAEC, GM19238, HeLa, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 69% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.211

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 56%, "14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, ZNF660, SOX2, XBP1, FOXA1, SUZ12, PBX2, RXRB, UBTF, KDM3A, BMI1, ATF3, ZFP64, CTCFL, ZBTB44, PRDM1, CHD7, ZNF444, RUNX3, MXD4, ZNF189, MECOM, PAX5, MITF, ZNF467, CDX2, JMJD1C, MAF, KLF5, ELF1, TRIM28, BCLAF1, KLF6, RBM39, ZNF557, TEAD1, ETV1, ESR1, ZNF121, MED26, RCOR2, NFE2L2, USF2, CTCF, TCF12, JUN, EP300, KLF1, E4F1, MNT, ZNF33A, LMO1, SOX5, DPF2, ZNF695, TRIM24, IRF4, RFX5, SOX6, DEK, PRKDC, E2F1, ZNF528, SMC1, ZNF280A, TEAD4, FOXA3, ZNF175, GTF2F1, PDX1, GATAD2A, EED, TFAP2C, GLIS1, RBPJ, EHMT2, POU2F2, CHD8, NANOG, ZNF263, BRD3, RUNX1T1, POU5F1, MYCN, CTBP1, ERF, ZBTB17, ZBTB48, ZSCAN21, CDK7, STAT1, SRF, GATAD1, SAP130, NBN, ARID3A, SP4, TBP, ERG, HOXC5, ZNF341, ETS1, MYC, EZH1, SMARCA4, KDM4A, ZNF2, RAD21, HOMEZ, GRHL3, FOXP2, KLF12, RXRA, NKX2-1, ARID1B, GABPA, ZNF8, XRCC5, STAT3, ZNF614, NKX3-1, APC, RCOR1, TERF2, ZNF639, NFE2, MIER3, NR2F6, DNMT3B, CEBPB, NR3C1, KMT2A, CREB1, CCAR2, EZH2, KLF8, JMJD6, BMPR1A, EBF3, GABPB1, ZHX2, SPI1, MIXL1, TFE3, HBP1, HDAC2, SSRP1, GATA2, ZNF644, ZNF182, MXD3, ZSCAN29, FLI1, HCFC1, DRAP1, SMARCA5, ZNF766, RELB, MRTFB, NFIL3, ZNF554, PTBP1, CC2D1A, ETV5, RUNX1, THAP11, SMC1A, BCL6, CEBPA, NKX2-2, CBX1, ZBTB24, AFF4, ZFX, SIN3A, SOX13, SMAD3, ZNF770, ZNF654, TRIM22, SMARCC1, ZNF549, ZBTB2, IRF2, NOTCH1, CREBBP, RARA, ZNF35, RUNX2, CDK6, PRPF4, RBBP5, ZNF384, ZNF184, ARNT, BACH1, CBX3, ZNF48, ATF2, SMAD4, NFYA, FOXM1, PBX3, MAFB, SMARCB1, HMGXB4, CDK8, MED1, TEAD3, ZXDB, MYB, SCRT2, U2AF1, SMAD1, PIAS1, ZBTB18, MAFG, L3MBTL2, C11orf30, SETDB1, MBD1, KLF16, RBM22, MAFK, BCL11A, SP1, GSPT2, HNF4A, ARID2, REST, IKZF5, ZHX1, ASH2L, HNRNPLL, PCGF2, BCOR, FOXP1, SMC3, ELL2, MLLT1, STAG1, STAG2, ZNF394, SKI, ZNF316, ZNF207, MTA3, TBL1X, CREM, CHD2, FOXA2, MIER2, ZNF600, GTF2B, WT1, MAFF, ZNF30, ZNF574, MEF2C, ZNF778, CDK9, HOXB13, ZKSCAN1, ZNF580, KDM1A, YY1, RELA, TARDBP, NEUROD1, ZFP36, HIF1A, TCF4, OTX2, GATA3, BATF, MAX, ZNF143, GATA1, KLF4, CEBPG, SP7, GFI1B, BCL11B, NCOA3, ZNF784, ZNF512, TCF7L2, KDM5B, TP53, NFKB1, PHOX2B, BRD2, ELF3, KAT8, PHF5A, T, TBX21, BHLHE40, AR, ARID4B, TAF1, ARRB1, ZBTB40, ZNF324, EGLN2, RB1, HSF1, ZBTB26, NOTCH3, SCRT1, ILF3, BRD4, JUND, NCOR1, MAZ, RNF2, TBX2, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): MRPL39,JAM2,GABPA,ATP5PF

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 16

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154721, ENSG00000154723, ENSG00000154727,

eachgene

Deatailed information for cohesin site CDBP00415306