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Basic information

CohesinDB ID: CDBP00415263

Locus: chr21-25576227-25589346

Data sourse: GSE93080, ENCSR000EAC, ENCSR000DZP, GSE67783, GSE98367, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR000BMY, GSE120943, GSE68388, GSE103477, GSE50893, GSE94872

Cell type: MDM, GM10847, GM2610, GM19240, HSPC, HuCC-T1, RPE, GM2630, Fibroblast, GM12890, GM2255, GM18486, GM18526, SNYDER, Monocytes, GM18505, GM12878, GM12891, GM2588, GM19239, RT-112, GM19193, THP-1, GM19099, Macrophage, GM12892, HUVEC, GM19238, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 11% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.678

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 61% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 50%, "4_Tx": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, CBX5, XBP1, FOXA1, LEO1, PBX2, TFAP4, TSC22D4, LYL1, BMI1, NFIC, ATF3, ZNF362, RUNX3, PRDM1, ATF4, CBFB, ZNF189, SMARCE1, PAX5, MAF, ELF1, BCLAF1, TEAD1, SMAD5, ESR1, HNF1B, USF2, CTCF, TCF12, JUN, EP300, ARID5B, LMO1, GATA6, SIX5, IRF4, SOX6, ZNF528, TEAD4, PDX1, EED, POU2F2, ZNF263, CDK7, TOP2A, CTBP1, DUX4, STAT1, NBN, ARID3A, ERG, ZNF597, NFKB2, ETS1, MYC, ZNF341, SMARCA4, OGG1, ARID1B, RAD21, GRHL3, RXRA, BATF3, GABPA, IKZF1, RCOR1, ZNF639, NR2F6, VDR, CEBPB, KMT2A, CREB1, EZH2, KLF8, EBF3, ZHX2, SPI1, GATA2, SMARCA5, RELB, RUNX1, SMC1A, HDAC1, LDB1, ZFX, TRIM22, CEBPZ, MEF2A, ZBTB2, ZNF384, RUNX2, GATA4, OSR2, DAXX, BACH1, PBX4, ATF2, HMGB2, FOXM1, ETV6, PBX3, SUPT5H, CBFA2T3, CDK8, MED1, ZEB1, PML, ZXDB, MYB, TERF1, ZMYM3, SMAD1, C11orf30, STAT5A, ZNF22, USF1, BCL11A, NIPBL, REST, ATF7, TCF3, STAT2, MLLT1, NFATC3, SKI, ZNF207, MTA3, CREM, HDAC6, NFATC1, E2F8, PAF1, ZNF600, ZBED1, GTF2B, EBF1, ZBTB33, TCF7, MEF2C, CDK9, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, SKIL, GATA3, BATF, TAL1, SPIB, GATA1, SP7, NR2F2, ZNF512, TCF7L2, NR2F1, KDM5B, ZNF687, PKNOX1, NFKB1, TBX21, AR, TAF1, ZNF366, EGR1, IKZF2, BRD4, JUND, NOTCH3, AHR, RUNX1-3

Target gene symbol (double-evidenced CRMs): APP,GABPA,ATP5PF,MRPL39,JAM2

Function elements

Human SNPs: Alzheimer's_disease

Number of somatic mutations (coding): 116

Number of somatic mutations (non-coding): 119

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154721, ENSG00000154723, ENSG00000154727, ENSG00000142192,

eachgene

Deatailed information for cohesin site CDBP00415263