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Basic information

CohesinDB ID: CDBP00415361

Locus: chr21-25969014-25969348

Data sourse: GSE111913, GSE67783

Cell type: RT-112, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SA1,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 66%, "4_Tx": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NME2, FOXA1, NFIC, ZFP64, PRDM1, TP63, ZNF736, BACH2, CDX2, JMJD1C, TEAD1, ELF1, BCLAF1, ETV1, TRIM28, LMO2, ESR1, SMAD5, JUN, CTCF, BAF155, IRF4, TRIM24, SMC1, TEAD4, KMT2B, RBPJ, TFAP2C, POU2F2, TOP2A, RUNX1T1, ZNF317, ZBTB48, STAT1, HOXC5, ERG, CHD4, ETS1, MYC, SMARCA4, RAD21, RXRA, GABPA, STAT3, NKX3-1, NFE2, TERF2, NR3C1, CEBPB, ESRRA, KMT2A, SPI1, EHF, IRF1, GATA2, FLI1, RELB, RUNX1, BCL6, SMC1A, CEBPA, SMAD3, MEF2A, CREBBP, ZNF35, ZBTB2, ZNF384, RUNX2, GATA4, ARNT, PBX4, DAXX, ETV6, FOS, CDK8, MED1, SPDEF, MYB, PIAS1, RBM22, MAFK, BCL11A, SP1, ATF7, POU2F3, ASH2L, BCOR, NCOR2, PAX7, MEF2B, FOXA2, RBBP5, EBF1, GTF2B, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, ISL1, TCF4, OTX2, GATA3, TAL1, MAX, SPIB, AGO2, TLE3, KLF4, NR2F2, PKNOX1, ZNF334, PHOX2B, ELF3, AR, TAF1, BRD4, AHR

Target gene symbol (double-evidenced CRMs): APP,CYYR1,GABPA

Function elements

Human SNPs: .

Number of somatic mutations (coding): 16

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000154727, ENSG00000142192, ENSG00000166265,

eachgene

Deatailed information for cohesin site CDBP00415361