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Basic information

CohesinDB ID: CDBP00415326

Locus: chr21-25871333-25873005

Data sourse: ENCSR000BLD, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE131606, GSE108869, GSE25021, ENCSR000BTU, GSE93080, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE101921, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, GSE68388, GSE83726, GSE126990, GSE50893

Cell type: RH4, GM2610, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, K-562, GM18486, GM18526, H1-hESC, SNYDER, MB157, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19099, HUES64, MCF-7, Hela-Kyoto, HCT-116, MCF-10A, Hep-G2, HUVEC, HCAEC, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 16% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.600

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 67%, "5_TxWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: POU2F2, SMC1A, CBX1, ZNF207, POU5F1, MYCN, CBX3, ZFX, POU4F2, MEIS2, XBP1, ZBTB48, TEAD4, SRF, KDM1A, YY1, RELA, ZBTB2, EHMT2, ETS1, RFX1, CTCFL, RAD21, THAP1, ARNT, GRHL3, NKX2-1, MAX, ZNF143, TEAD1, TRIM28, SNAI2, SMAD1, ESR1, OCA2, ZNF334, CTCF, ZHX2, SPI1, ZBTB7A, FLI1, MAZ, AATF, SMC1, SMC3, STAG1

Target gene symbol (double-evidenced CRMs): GABPA,CYYR1,MRPL39,APP

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154727, ENSG00000142192, ENSG00000166265,

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Deatailed information for cohesin site CDBP00415326