- Basic information
- CohesinDB ID: CDBP00415566
- Locus: chr21-26806617-26807296
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Data sourse: GSE206145-NatGen2015, ENCSR000ECS, GSE68388, GSE165895
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Cell type: HeLa-S3, Fibroblast, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: Mau2,SMC3,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
41% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 76%,
"7_Enh": 10%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: ZNF394, FOSL1, ZNF692, ZBTB17, SMAD3, FOXA1, HIC1, HOXB13, TBP, SMARCC1, ERG, KDM1A, RELA, ZNF384, ZNF35, JUNB, RUNX2, ZNF362, OSR2, PBX4, DAXX, GATA3, GABPA, ZNF189, STAT3, FOS, ZNF639, NR3C1, CEBPB, MYB, SCRT2, SNAI2, SETDB1, NFKB1, ZNF22, JUN, ELF3, BRD2, SPI1, EP300, BAF155, EHF, AR, IRF1, LMO1, ZHX1, FLI1, BRD4, JUND, FOSL2
- Target gene symbol (double-evidenced CRMs): APP,GABPA,MRPL39
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 12
- Related genes and loops
- Related gene:
ENSG00000154719,
ENSG00000154727,
ENSG00000142192,
- Related loop:
chr21:25300000-25325000~~chr21:26800000-26825000,
chr21:25575000-25600000~~chr21:26800000-26825000,
chr21:25775000-25800000~~chr21:26800000-26825000,
chr21:25950000-25975000~~chr21:26800000-26825000,
chr21:26150000-26175000~~chr21:26800000-26825000,
chr21:26375000-26400000~~chr21:26800000-26825000,
chr21:26800000-26825000~~chr21:28225000-28250000,
chr21:26800000-26825000~~chr21:28725000-28750000,
chr21:26800000-26825000~~chr21:28950000-28975000,