- Basic information
- CohesinDB ID: CDBP00415276
- Locus: chr21-25647707-25648230
-
Data sourse: GSE67783, GSE98367
-
Cell type: HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 0% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: SA1,SMC1
-
CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
61% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 74%,
"7_Enh": 9%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: RUNX1, SKI, SMC1A, MEF2B, FOXA1, MEF2C, CDK9, ERG, KDM1A, MEF2A, RUNX3, GATA3, MAX, GATA1, IKZF1, CDK8, JMJD1C, TRIM28, KMT2A, TCF7L2, MLL, EVI1, CTCF, SPI1, BCL11A, GATA2, TRIM24, BRD4, KMT2B
- Target gene symbol (double-evidenced CRMs): JAM2,ADAMTS1,GABPA,APP,ATP5PF
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 12
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000154721,
ENSG00000154723,
ENSG00000154727,
ENSG00000142192,
ENSG00000154734,
- Related loop:
chr21:25625000-25650000~~chr21:25725000-25750000,
chr21:25625000-25650000~~chr21:25775000-25800000,
chr21:25625000-25650000~~chr21:26150000-26175000,
chr21:25625000-25650000~~chr21:26825000-26850000,
chr21:25625000-25650000~~chr21:28050000-28075000,
chr21:25650000-25675000~~chr21:26525000-26550000,
chr21:25650000-25675000~~chr21:26925000-26950000,