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Basic information

CohesinDB ID: CDBP00415362

Locus: chr21-25970446-25971016

Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE98367, GSE105028, GSE206145-NatGen2015, GSE83726, ENCSR703TNG, GSE25021, GSE116344

Cell type: MCF-7, Fibroblast, RH4, Liver, Macrophage, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 37%, "4_Tx": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, CHD8, NKX2-2, SIN3A, SMAD3, FOXA1, HOXB13, ZNF300, HNRNPK, ERG, RELA, CREBBP, ZNF384, YY1, ZNF35, MYC, RAD21, ZBTB44, PBX4, DAXX, GATA3, GABPA, ZNF189, STAT3, NRIP1, NKX3-1, NR3C1, CEBPB, ESRRA, NCOA3, TEAD1, CEBPD, CREB1, PIAS1, TFAP2C, ESR1, ZBTB6, KLF8, SETDB1, JUN, RBM22, SPI1, BAF155, EP300, AR, PCBP1, HDAC2, GATA2, ZNF366, FLI1, ASH2L, BRD4, FOXP1, CLOCK, MRTFB, NCOA2, ZNF554, PDX1, AHR

Target gene symbol (double-evidenced CRMs): CYYR1,APP,GABPA

Function elements

Human SNPs: .

Number of somatic mutations (coding): 64

Number of somatic mutations (non-coding): 8

Related genes and loops

Related gene: ENSG00000154727, ENSG00000142192, ENSG00000166265,

eachgene

Deatailed information for cohesin site CDBP00415362