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Basic information

CohesinDB ID: CDBP00415268

Locus: chr21-25606719-25610187

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 85% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.089

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 61% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "2_TssAFlnk": 32%, "1_TssA": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, RXRB, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, MORC2, PAX5, TEAD1, ZNF121, SNAPC1, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, ZNF75A, SOX5, ZNF407, E2F4, DEK, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, BRD3, POU5F1, TOP2A, ZNF263, CTBP1, ZMYND11, ERF, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, NR2C2, DRAP1, MXI1, RELB, EP400, RUNX1, ZMYM2, HDAC1, NKX2-2, CEBPA, ZNF707, IRF3, REPIN1, ZNF654, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZXDC, ZBTB2, TFDP1, ZBTB10, ELK1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, ZNF331, NR1H2, C11orf30, EVI1, MBD1, STAT5A, GSPT2, ARID2, IKZF5, OVOL3, AFF1, MBD2, ELL2, ETV4, NFATC3, ZSCAN18, MEF2B, ZNF207, CBX3, CREM, CHD2, NFATC1, PAF1, SS18, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, ZNF333, PLAG1, ZFP69B, BCL11B, KLF4, ZNF784, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ADNP, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, ZNF101, PBX2, HNRNPK, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, WDHD1, CBFB, ZSCAN4, TP63, MITF, CDC5L, ZNF467, MAF, INTS11, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, ZNF624, FUS, CTCF, TAF3, JUN, L3MBTL4, ZBTB20, MNT, LMO1, RYBP, DPF2, SIX5, IRF4, ZNF423, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, ZNF317, NONO, SRF, NBN, CHD4, ZNF626, ONECUT1, TRIP13, KDM4A, ZNF2, HOMEZ, FOXP2, TSHZ1, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, LDB1, SOX13, AFF4, POU4F2, ZFP3, ZNF770, ZMIZ1, ZNF18, ZNF792, CEBPZ, SP3, ARNT, BACH1, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, ETV6, MAFB, HMGXB4, ZNF10, TEAD3, DIDO1, ZXDB, ZNF680, U2AF1, TAF7, KLF9, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, STAT2, MLLT1, STAG1, STAG2, ZNF394, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, KLF7, KDM1A, BCL3, ZNF222, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF645, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, ARRB1, TBX21, ZFP41, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, SMAD4.1D12, TBX2, IRF9, PGR, FANCL, CBX5, PATZ1, LEO1, UBTF, SMAD1-5, TFAP4, SIN3B, BMI1, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, ZNF217, ESR1, SAP30, ZNF524, SND1, KLF1, ZNF695, SOX9, ZNF260, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ASH1L, ZSCAN5A, ELK4, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, PHF21A, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, INO80, DNMT3B, YBX3, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, TAF9B, ZNF777, NCOA2, ZNF76, ZNF554, ETV5, GTF2A2, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, MEF2A, RARA, NFYC, ZNF35, CREBBP, TAF15, ZNF384, ZNF518A, SMAD4, CDK8, ZEB1, ZMYM3, NCOA1, GTF3C2, SREBF2, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, ZNF816, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, YY2, FOXO3, RELA, TARDBP, CHAMP1, ZNF282, SKIL, MAX, GFI1B, NEUROG2, NR2F1, KDM5B, TCF7L2, PKNOX1, RUVBL1, MYOD1, KMT2D, AR, YAP1, ZNF324, HEXIM1, ZNF280D, AHR, DMAP1, FOSL2, ZNF391, HMG20A, HMGN3, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, ZNF362, CTCFL, ZBTB5, PRDM1, KLF14, MECOM, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, ZFP91, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, SOX6, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, GATAD1, GMEB2, ARID3A, USP7, MIER1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, TCF25, ZNF639, ZNF501, JMJD6, FEZF1, TFE3, EHF, ZNF664, IRF1, HBP1, GTF3C5, ZGPAT, MRTFB, ZC3H11A, ZIM3, MYF5, ATF1, PTBP1, ZNF45A, CBX1, SMC1A, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, NMYC, NSD2, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, SMAD2, ZSCAN30, NRF1, GR, PBX4, NR2C1, CHD1, SUPT5H, FOS, TGIF2, MED1, KDM6B, MYB, SCRT2, CEBPD, ZNF558, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, TAF2, SKI, NELFA, ZNF283, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF843, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): ADAMTS1,GABPA,APP,CYYR1,MRPL39,ATP5PF,JAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 48

Number of somatic mutations (non-coding): 12

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154721, ENSG00000154723, ENSG00000154727, ENSG00000142192, ENSG00000166265, ENSG00000154734,

eachgene

Deatailed information for cohesin site CDBP00415268