- Basic information
- CohesinDB ID: CDBP00415220
- Locus: chr21-25420705-25426209
-
Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE126634, ENCSR000BLY, GSE105028, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE143937, GSE115250, GSE138405, GSE101921, GSE135093, GSE152721, GSE120943, ENCSR198ZYJ, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE138105, GSE145327, GSE94872, ENCSR000EEG, GSE76815, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, GSE62063, ENCSR000BMY, ENCSR000EHX, ENCSR984DZW, GSE97394, GSE55407, ENCSR000BTQ, GSE38395, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, GSE155324, GSE38411, ENCSR000EDE, GSE68388, GSE126990, GSE50893, GSE131577
-
Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, CVI-hiPSC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, HUES9, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, TC-71, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 43% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.300
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
35% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 62%,
"7_Enh": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, CBX5, ZNF660, SOX2, XBP1, FOXA1, HDGF, TSC22D4, NFIC, CTCFL, RUNX3, PRDM1, CBFB, PAX5, TP63, MAF, ELF1, BCLAF1, TRIM28, KLF6, SNAI2, SMAD5, ESR1, MLL, ZNF217, USF2, CTCF, SND1, TCF12, DPF2, PAX8, IRF4, RAD51, TEAD4, GTF2F1, RBPJ, EED, POU2F2, CHD8, ZSCAN5D, TOP2A, CDK7, MTA2, DUX4, ZBTB48, STAT1, ZNF205, SRF, NBN, ARID3A, ZNF224, TBP, ERG, OGG1, ZNF597, NFKB2, MYC, RAD21, GRHL3, RXRA, NKX2-1, BATF3, GABPA, STAT3, IKZF1, TERF2, NR3C1, CEBPB, STAT5B, KMT2A, CREB1, EZH2, SPI1, IRF1, GATA2, GATAD2B, FLI1, DRAP1, SMARCA5, RELB, RUNX1, BCL6, SMC1A, MAFG, EZH2phosphoT487, AFF4, ZFX, ZNF654, TRIM22, MEF2A, CREBBP, ZNF384, ZBTB2, RUNX2, GATA4, ARNT, PBX4, SOX11, ATF2, PRDM9, ZNF48, ETV6, PBX3, FOXM1, FOS, CDK8, MED1, PML, TERF1, MYB, SMAD1, C11orf30, SETDB1, EVI1, STAT5A, MAFK, BCL11A, NIPBL, SP1, REST, ATF7, ASH2L, HOXA9, TCF3, FOXP1, SMC3, STAT2, MLLT1, STAG1, STAG2, NFATC3, MEF2B, ZNF316, FOXA2, MTA3, EBF1, CREM, NFATC1, ZNF207, MEIS1, E2F8, ZBED1, GTF2B, MEF2C, TCF7, CDK9, HOXB13, BCL3, YY1, RELA, TARDBP, JUNB, BRCA1, SKIL, HIF1A, GATA3, BATF, MAX, SPIB, GATA1, ZNF143, NCOA3, KDM5B, ZNF687, PKNOX1, TP53, MED, ZNF334, NFKB1, PHOX2B, BRD2, ELF3, TBX21, BHLHE40, AR, TAF1, ZBTB40, RB1, IKZF2, BRD4, JUND, SCRT1, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): APP,JAM2,MRPL39,ATP5PF,GABPA
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 11
- Related genes and loops
- Related gene:
ENSG00000154719,
ENSG00000154721,
ENSG00000154723,
ENSG00000154727,
ENSG00000142192,
- Related loop:
chr21:25400000-25425000~~chr21:25550000-25575000,
chr21:25400000-25425000~~chr21:25575000-25600000,
chr21:25400000-25425000~~chr21:25600000-25625000,
chr21:25400000-25425000~~chr21:25700000-25725000,
chr21:25400000-25425000~~chr21:25725000-25750000,
chr21:25400000-25425000~~chr21:25775000-25800000,
chr21:25400000-25425000~~chr21:26150000-26175000,
chr21:25420529-25422993~~chr21:25566907-25568446,
chr21:25420529-25422993~~chr21:25606735-25609548,
chr21:25420540-25423403~~chr21:25560910-25563164,
chr21:25420540-25423403~~chr21:25606733-25609495,
chr21:25420678-25422766~~chr21:25560847-25563165,
chr21:25420678-25422766~~chr21:25573354-25574752,
chr21:25420712-25422853~~chr21:25560936-25563164,
chr21:25420779-25423371~~chr21:25560899-25563117,
chr21:25420779-25423371~~chr21:25566872-25568350,
chr21:25420779-25423371~~chr21:25606803-25609752,
chr21:25420786-25422730~~chr21:25455832-25458166,
chr21:25420786-25422730~~chr21:25559998-25563081,
chr21:25420786-25422730~~chr21:25566885-25568380,
chr21:25420827-25422906~~chr21:25566845-25568434,
chr21:25420827-25422906~~chr21:25576959-25578131,
chr21:25420833-25423377~~chr21:25559917-25563022,
chr21:25420835-25423361~~chr21:25560463-25563063,
chr21:25420835-25423361~~chr21:25567081-25568291,
chr21:25420881-25422831~~chr21:25566913-25568404,
chr21:25420881-25422831~~chr21:25606865-25609546,
chr21:25420903-25423353~~chr21:25567034-25568326,
chr21:25420928-25423279~~chr21:25561015-25562774,
chr21:25420928-25423279~~chr21:25567075-25568299,
chr21:25420945-25422989~~chr21:25561564-25562715,
chr21:25421193-25422730~~chr21:25606816-25609496,
chr21:25421231-25422782~~chr21:25861820-25863486,
chr21:25423746-25424928~~chr21:25455834-25458451,
chr21:25423746-25424928~~chr21:25560899-25563117,
chr21:25425000-25450000~~chr21:25550000-25575000,
chr21:25425000-25450000~~chr21:25700000-25725000,