- Basic information
- CohesinDB ID: CDBP00415360
- Locus: chr21-25965954-25968091
-
Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE98367, ENCSR000BLY, GSE206145, GSE101921, GSE62063, GSE50893, ENCSR000BMY, GSE120943, GSE111537, GSE116344, GSE126755, ENCSR917QNE
-
Cell type: MCF-7, RPE, RH4, Monocytes, GM12878, HCAEC, OCI-AML-3, SK-N-SH, GM19239, Liver, Neutrophil, Macrophage, Ramos
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.856
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
-
CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 48%,
"7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: NME2, FOXA1, NFIC, ZFP64, PRDM1, TP63, ZNF736, BACH2, CDX2, JMJD1C, TEAD1, ELF1, BCLAF1, ETV1, TRIM28, LMO2, ESR1, SMAD5, JUN, CTCF, BAF155, IRF4, TRIM24, SMC1, TEAD4, KMT2B, RBPJ, TFAP2C, POU2F2, TOP2A, RUNX1T1, ZNF317, ZBTB48, STAT1, HOXC5, ERG, CHD4, ETS1, MYC, SMARCA4, RAD21, RXRA, GABPA, STAT3, NKX3-1, NFE2, TERF2, NR3C1, CEBPB, ESRRA, KMT2A, SPI1, EHF, IRF1, GATA2, FLI1, RELB, RUNX1, BCL6, SMC1A, CEBPA, SMAD3, MEF2A, CREBBP, ZNF35, ZBTB2, ZNF384, RUNX2, GATA4, ARNT, PBX4, DAXX, ETV6, FOS, CDK8, MED1, SPDEF, MYB, PIAS1, RBM22, MAFK, BCL11A, SP1, ATF7, POU2F3, ASH2L, BCOR, NCOR2, PAX7, MEF2B, FOXA2, RBBP5, EBF1, GTF2B, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, ISL1, TCF4, OTX2, GATA3, TAL1, MAX, SPIB, AGO2, TLE3, KLF4, NR2F2, PKNOX1, ZNF334, PHOX2B, ELF3, AR, TAF1, BRD4, AHR
- Target gene symbol (double-evidenced CRMs): APP,CYYR1,GABPA
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 56
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000154727,
ENSG00000142192,
ENSG00000166265,
- Related loop:
chr21:25750000-25775000~~chr21:25950000-25975000,
chr21:25775000-25800000~~chr21:25950000-25975000,
chr21:25924913-25927132~~chr21:25962734-25964839,
chr21:25950000-25975000~~chr21:26050000-26075000,
chr21:25950000-25975000~~chr21:26075000-26100000,
chr21:25950000-25975000~~chr21:26125000-26150000,
chr21:25950000-25975000~~chr21:26150000-26175000,
chr21:25950000-25975000~~chr21:26250000-26275000,
chr21:25950000-25975000~~chr21:26375000-26400000,
chr21:25950000-25975000~~chr21:26525000-26550000,
chr21:25950000-25975000~~chr21:26800000-26825000,