- Basic information
- CohesinDB ID: CDBP00415275
- Locus: chr21-25646355-25647152
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Data sourse: GSE126634, GSE152721, GSE120943, GSE98367
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Cell type: Monocytes, HAP1, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: Rad21,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
61% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 66%,
"7_Enh": 12%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, CHD8, SOX2, NME2, FOXA1, ERG2, SP4, HOXB13, ZNF596, SMARCC1, RELA, MYC, RUNX2, SMARCA4, MCM3, CHD7, ARNT, HIF1A, PRDM1, GRHL3, PBX3, NKX3-1, GATA1, TRIM28, KDM5B, EZH2, FEZF1, AR, HSF1, PHIP, PRDM6, SMC1, ZIM3
- Target gene symbol (double-evidenced CRMs): JAM2,GABPA,APP,ATP5PF,ADAMTS1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 21
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000154721,
ENSG00000154723,
ENSG00000154727,
ENSG00000142192,
ENSG00000154734,
- Related loop:
chr21:25625000-25650000~~chr21:25725000-25750000,
chr21:25625000-25650000~~chr21:25775000-25800000,
chr21:25625000-25650000~~chr21:26150000-26175000,
chr21:25625000-25650000~~chr21:26825000-26850000,
chr21:25625000-25650000~~chr21:28050000-28075000,
chr21:25650000-25675000~~chr21:26525000-26550000,
chr21:25650000-25675000~~chr21:26925000-26950000,