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Basic information

CohesinDB ID: CDBP00415926

Locus: chr21-28332778-28340251

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE132649, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE105028, GSE73207, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000EAC, GSE115250, GSE138405, GSE76893, GSE101921, GSE135093, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE106870, GSE116344, GSE138105, GSE145327, GSE85526, ENCSR895JMI, GSE94872, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE76815, GSE98367, ENCSR193NSH, GSE206145, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR635OSG, ENCSR748MVX, ENCSR767DFK, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE55407, ENCSR944ZCT, GSE129526, ENCSR000HPG, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM2610, SLK, CVB-hiPSC, CVI-hiPSC, Liver, Transformed-RPE1, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, TF-1, GM12878, GM12891, GM2588, SK-N-SH, HeLa-Tet-On, THP-1, Macrophage, HUES64, MCF-7, T-47D, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, OCI-AML-3

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 51% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.400

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 35% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 53%, "7_Enh": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, HMG20A, E2F7, XBP1, FOXA1, KDM3A, ATF3, NFIC, CHD7, PAX5, TP63, TEAD1, ELF1, ETV1, SNAI2, RCOR2, ESR1, CTCF, JUN, TCF12, EP300, BAF155, SOX5, GATA6, IRF4, RFX5, DEK, ZNF808, SMC1, TEAD4, GATAD2A, PDX1, GTF2F1, CHD8, MYCN, TOP2A, ERF, DUX4, STAT1, SRF, GATAD1, SAP130, BAHD1, ARID3A, HNF4G, HOXC5, ERG, ETS1, ONECUT1, MYC, SMARCA4, RAD21, RXRA, GABPA, STAT3, NKX3-1, RCOR1, NR2F6, ARNTL, NR3C1, CEBPB, TBL1XR1, EBF3, MIXL1, EHF, GATA2, ZGPAT, MXI1, NFIL3, ZIM3, RUNX1, THAP11, BCL6, SMC1A, CEBPA, EZH2phosphoT487, NKX2-2, SIN3A, SMAD3, ZNF654, TRIM22, SMARCC1, TWIST1, ZBTB2, ZNF384, RARA, RUNX2, CDK6, GATA4, PBX4, PBX3, FOS, HMGXB4, CHD1, MED1, TEAD3, ZEB1, CEBPD, PIAS1, SMAD1, MAFK, SP1, BCL11A, HNF4A, REST, ARID1A, ZHX1, BCOR, FOXP1, SMC3, STAG1, STAG2, FOXA2, EBF1, CHD2, ZSCAN16, ZBTB33, HOXB13, YY1, RELA, JUNB, BRG1, HIF1A, GATA3, MAX, ZNF143, GATA1, HAND2, KLF4, CEBPG, NR2F2, KDM5B, TP53, NFKB1, MYOD1, PHOX2B, ELF3, KAT8, BHLHE40, AR, TAF1, YAP1, EGR1, NOTCH3, BRD4, JUND, TBX2, BRCA1, FOSL2

Target gene symbol (double-evidenced CRMs): LTN1,ADAMTS5,LINC00113,ADAMTS1

Function elements

Human SNPs: Iris_color_(L*_coordinate)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 56

Related genes and loops

Related gene: ENSG00000154734, ENSG00000154736, ENSG00000225298, ENSG00000198862,

eachgene

Deatailed information for cohesin site CDBP00415926