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Basic information

CohesinDB ID: CDBP00415700

Locus: chr21-27362042-27362950

Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, GSE116868, ENCSR000BLY, GSE105028, GSE111537, GSE25021, GSE108869, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE138405, GSE101921, GSE206145-NatGen2015, GSE138105, GSE130135, GSE116344, ENCSR703TNG, GSE94872, GSE206145, GSE85526, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR000HPG, ENCSR000EDE, GSE68388, GSE126990, GSE50893, ENCSR000ECS

Cell type: RH4, GM2610, SLK, Liver, HuCC-T1, H9-hESC, RPE, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, H1-hESC, MB157, SK-N-SH, HUES64, MCF-7, Hela-Kyoto, HEK293T, HUVEC, HCAEC, OCI-AML-3

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 15% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.744

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 36% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 96%, "5_TxWk": 3%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: SMC1A, FOXA2, NKX2-2, POU5F1, STAG2, DUX4, FOXA1, SRF, HOXB13, RELA, RFX1, RAD21, GRHL3, HIF1A, CREB1, CTCF, BAF155, GATA2, BCOR, SMC1, SMC3, STAG1

Target gene symbol (double-evidenced CRMs): ADAMTS1,ADAMTS5

Function elements

Human SNPs: Dialysis-related_mortality

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 10

Related genes and loops

Related gene: ENSG00000154734, ENSG00000154736,

eachgene

Deatailed information for cohesin site CDBP00415700