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Basic information

CohesinDB ID: CDBP00415975

Locus: chr21-28536526-28542170

Data sourse: ENCSR000EFJ, ENCSR230ZWH, GSE67783, GSE165895, ENCSR000HPG, ENCSR000BLY, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR917QNE

Cell type: RPE, Fibroblast, IMR-90, SK-N-SH, RT-112, Liver, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 9% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 38% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 65%, "7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, E2F7, SOX2, FOXA1, ATF3, NFIC, PRDM1, CDX2, KLF6, NFE2L2, HNF1B, USF2, JUN, TCF12, BAF155, EP300, E2F1, TEAD4, POU5F1, MYCN, DUX4, ZBTB48, BAHD1, HIC1, ERG, HOXC5, MYC, SMARCA4, RAD21, LHX2, GRHL3, RXRA, STAT3, RCOR1, VDR, NR3C1, CEBPB, ZNF750, KLF8, EBF3, SPI1, EHF, IRF1, GATA2, EZH2phosphoT487, SMAD3, SMARCC1, MEF2A, RUNX2, CDK6, GATA4, PBX4, DAXX, PBX3, FOXM1, FOS, CHD1, MED1, CEBPD, PIAS1, NR1H2, USF1, MAFK, HNF4A, FOXP1, PPARG, FOXA2, ZBTB33, HOXB13, YY1, RELA, JUNB, GATA3, MAX, GATA1, KLF4, NR2F2, NFKB1, ELF3, BHLHE40, AR, BRD4, JUND, FOSL2

Target gene symbol (double-evidenced CRMs): LINC00113,LTN1,ADAMTS1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 32

Related genes and loops

Related gene: ENSG00000154734, ENSG00000225298, ENSG00000198862,

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Deatailed information for cohesin site CDBP00415975