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Basic information

CohesinDB ID: CDBP00415731

Locus: chr21-27475441-27478394

Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE103477, GSE111537, GSE25021, GSE108869, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE138405, GSE101921, GSE135093, GSE206145-NatGen2015, ENCSR198ZYJ, GSE112028, GSE130135, GSE138105, GSE94872, GSE76815, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR000BTQ, GSE105004, ENCSR000HPG, ENCSR000EDE, GSE68388, GSE126990, ENCSR000ECS

Cell type: SLK, Liver, HuCC-T1, H9-hESC, RPE, HMEC, Fibroblast, Ishikawa, HeLa-S3, IMR-90, H1-hESC, SK-N-SH, HeLa-Tet-On, THP-1, HUES64, MCF-7, Hela-Kyoto, MCF-10A, HEK293T, Neurons-H1, HUVEC, HCAEC, HeLa, OCI-AML-3

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 23% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.733

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 36% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 69%, "7_Enh": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: SMC1A, NKX2-2, SOX2, FOXA1, HOXB13, SMARCC1, RAD21, RXRA, GATA3, PBX3, PIAS1, STAG1, CTCF, ELF3, TCF12, MAFK, GATA2, BRD4, SMC1, SMC3, STAG2

Target gene symbol (double-evidenced CRMs): ADAMTS1,ADAMTS5

Function elements

Human SNPs: Electrocardiogram_morphology_(amplitude_at_temporal_datapoints)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 26

Related genes and loops

Related gene: ENSG00000154734, ENSG00000154736,

eachgene

Deatailed information for cohesin site CDBP00415731