- Basic information
- CohesinDB ID: CDBP00415331
- Locus: chr21-25887111-25887606
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Data sourse: ENCSR000BLD, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE126634, ENCSR000BLY, GSE105028, GSE121355, GSE131606, GSE25021, GSE93080, ENCSR000BKV, GSE76893, GSE101921, GSE135093, ENCSR703TNG, GSE116344, ENCSR000EEG, ENCSR000BLS, ENCSR000EHW, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, GSE55407, GSE110061, GSE129526, GSE68388, GSE50893
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Cell type: RH4, GM2610, GM19240, Liver, HuCC-T1, H9-hESC, GM2630, IMR-90, K-562, GM18486, DKO, H1-hESC, GM12878, GM12891, GM2588, SK-N-SH, GM19239, GM19193, THP-1, MCF-7, GM12892, HCT-116, Hep-G2, HCAEC, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 11% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.722
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
67% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 48%,
"4_Tx": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, HMG20A, HNF1A, FOXA1, RXRB, ATF3, THRB, PRDM1, ZNF273, CDX2, TEAD1, KLF6, ETV1, SNAI2, RCOR2, ESR1, OCA2, HNF1B, JUN, CTCF, BAF155, EP300, SOX5, SMC1, FOXA3, GATAD2A, NANOG, CHD8, ZSCAN5D, POU5F1, SRF, SAP130, ARID3A, HNF4G, ERG, HOXC5, ETS1, MYC, ONECUT1, HOMEZ, RAD21, GRHL3, RXRA, PROX1, NKX2-1, GABPA, NKX3-1, DNMT3B, NR2F6, NR3C1, CEBPB, EZH2, GABPB1, MIXL1, IRF1, GATA2, ZNF644, FLI1, NFIL3, ETV5, SMC1A, BCL6, CEBPA, NKX2-2, SOX13, ZFX, SMAD3, SMARCC1, RARA, ZNF384, CDK6, GR, DAXX, ARNT, ATF2, HMBOX1, SMAD4, FOS, MED1, ZEB1, TEAD3, PIAS1, C11orf30, RBM22, MAFK, NIPBL, SP1, HNF4A, ARID1A, POU2F3, ASH2L, FOXP1, SMC3, NCOR2, STAG1, ETV4, PPARG, FOXA2, NFATC1, PAF1, MAFF, FOXF1, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, NEUROD1, JUNB, SP140, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, TLE3, KLF4, CEBPG, NR2F2, NEUROG2, TCF7L2, TP53, ELF3, PHF5A, KAT8, AR, PAX3-FOXO1, ZBTB26, BRD4, JUND, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): CYYR1,ADAMTS1,APP,MRPL39
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 8
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000154719,
ENSG00000142192,
ENSG00000166265,
ENSG00000154734,
- Related loop:
chr21:25600000-25625000~~chr21:25875000-25900000,
chr21:25875000-25900000~~chr21:25975000-26000000,
chr21:25875000-25900000~~chr21:26050000-26075000,
chr21:25875000-25900000~~chr21:26150000-26175000,
chr21:25875000-25900000~~chr21:26175000-26200000,
chr21:25875000-25900000~~chr21:26325000-26350000,
chr21:25875000-25900000~~chr21:26375000-26400000,
chr21:25875000-25900000~~chr21:26400000-26425000,
chr21:25875000-25900000~~chr21:26525000-26550000,
chr21:25875000-25900000~~chr21:26675000-26700000,
chr21:25875000-25900000~~chr21:26700000-26725000,
chr21:25875000-25900000~~chr21:26825000-26850000,
chr21:25875000-25900000~~chr21:28725000-28750000,
chr21:25880592-25882759~~chr21:26168595-26171726,
chr21:25880592-25882759~~chr21:26715468-26718051,
chr21:25880643-25882866~~chr21:26000836-26002126,
chr21:25880643-25882866~~chr21:26169947-26171806,
chr21:25880643-25882866~~chr21:26715421-26718120,
chr21:25880719-25882754~~chr21:26168603-26171485,
chr21:25880719-25882754~~chr21:26716644-26718024,
chr21:25880755-25882952~~chr21:26168541-26171786,
chr21:25880755-25882952~~chr21:26715348-26718310,
chr21:25880758-25882873~~chr21:26715355-26718381,
chr21:25880762-25882939~~chr21:26168567-26172542,
chr21:25880762-25882939~~chr21:26715356-26718205,
chr21:25880770-25883137~~chr21:26168491-26171741,
chr21:25880770-25883137~~chr21:26715200-26718356,
chr21:25880785-25882961~~chr21:26168597-26171877,
chr21:25880785-25882961~~chr21:26715447-26718081,
chr21:25880794-25882895~~chr21:26168600-26171765,
chr21:25880794-25882895~~chr21:26715448-26718086,
chr21:25880795-25883103~~chr21:26168579-26171699,
chr21:25880795-25883103~~chr21:26714832-26718268,
chr21:25880802-25883195~~chr21:26715193-26718542,
chr21:25880806-25883113~~chr21:26168567-26171752,
chr21:25880806-25883113~~chr21:26715204-26718284,
chr21:25880813-25882766~~chr21:26170075-26171770,
chr21:25880813-25882766~~chr21:26715409-26718024,
chr21:25880821-25883172~~chr21:26168566-26171735,
chr21:25880821-25883172~~chr21:26715280-26718256,
chr21:25880823-25883149~~chr21:26587219-26589182,
chr21:25880823-25883149~~chr21:26715242-26718467,
chr21:25880831-25882882~~chr21:26168509-26171714,
chr21:25880831-25882882~~chr21:26715317-26718206,
chr21:25880833-25882973~~chr21:25999508-26002814,
chr21:25880833-25882973~~chr21:26715347-26718278,
chr21:25880854-25882845~~chr21:26170145-26171780,
chr21:25880871-25883139~~chr21:26168536-26171703,
chr21:25880871-25883139~~chr21:26715160-26718522,
chr21:25880873-25883193~~chr21:26715252-26718261,
chr21:25880878-25883186~~chr21:26000596-26002821,
chr21:25880878-25883186~~chr21:26031390-26033174,
chr21:25880878-25883186~~chr21:26169836-26171640,
chr21:25880878-25883186~~chr21:26715477-26718366,
chr21:25880879-25883157~~chr21:25999375-26002832,
chr21:25880879-25883157~~chr21:26715196-26718405,
chr21:25880888-25882763~~chr21:26000649-26002298,
chr21:25880911-25882804~~chr21:26715538-26718232,
chr21:25880913-25882748~~chr21:26169335-26171730,
chr21:25880921-25883079~~chr21:26715396-26718303,
chr21:25880943-25882795~~chr21:26715485-26718222,
chr21:25880959-25882727~~chr21:26168566-26171728,
chr21:25881104-25882779~~chr21:26715351-26718059,
chr21:25881105-25882920~~chr21:26168579-26171721,
chr21:25881130-25882858~~chr21:26715239-26718238,
chr21:25886689-25887960~~chr21:26168542-26171691,
chr21:25886700-25888011~~chr21:26715421-26718120,
chr21:25886797-25887944~~chr21:26715196-26718405,