- Basic information
- CohesinDB ID: CDBP00415998
- Locus: chr21-28631051-28640482
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Data sourse: ENCSR000EFJ, GSE73207, GSE67783, GSE98367, ENCSR000HPG, ENCSR000BLY, GSE111913, GSE206145, GSE101921, GSE85526, GSE206145-NatGen2015, ENCSR000EDE, ENCSR000EHX, GSE68388, GSE108869, GSE94872, ENCSR000ECS, GSE165895
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Cell type: RPE, Macrophage, HMEC, Fibroblast, HEKn, TF-1, HUVEC, HCAEC, HeLa-S3, IMR-90, SK-N-SH, RT-112, HSPC, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 15% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.833
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
38% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 36%,
"7_Enh": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, SOX2, HNF1A, XBP1, FOXA1, TFAP4, LYL1, ATF3, NFIC, TP63, MITF, KLF5, TEAD1, TRIM28, KLF6, SNAI2, NFE2L2, LMO2, ESR1, HNF1B, TP73, MED26, JUN, TCF12, CTCF, BAF155, EP300, E2F1, SMC1, ZNF350, TEAD4, TFAP2C, NANOG, ZBTB48, STAT1, ZNF205, ZNF300, ERG, HOXC5, ETS1, MYC, RAD21, RXRA, GABPA, STAT3, UBN1, NKX3-1, NFE2, RCOR1, VDR, ARNTL, NR3C1, CEBPB, ZNF750, KMT2A, CREB1, FEZF1, GRHL2, EBF3, TRPS1, ZHX2, SPI1, EHF, IRF1, GATA2, SIX2, FLI1, RUNX1, SMC1A, CEBPA, LDB1, SIN3A, SMAD3, MEF2A, ZNF384, RUNX2, GATA4, GR, PBX4, NRF1, DAXX, HMGB2, PBX3, FOXM1, MAFB, FOS, CDK8, MED1, PIAS1, TBX5, SETDB1, EVI1, MAFK, BCL11A, SP1, NKX2-5, REST, ARID1A, ZHX1, CTBP2, FOXP1, STAG2, PPARG, FOXA2, CHD2, GTF2B, ZBTB33, HOXB13, KDM1A, YY1, RELA, JUNB, HIF1A, GATA3, TAL1, MAX, NRIP1, GATA1, TLE3, ZFP69B, KLF4, GFI1B, NR2F2, NCOA3, TCF7L2, TP53, NFKB1, ELF3, BHLHE40, AR, TAF1, ZBTB16, RXR, NCOR1, BRD4, JUND, FOSL2
- Target gene symbol (double-evidenced CRMs): ADAMTS1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000154734,
- Related loop:
chr21:25350000-25375000~~chr21:28625000-28650000,
chr21:26825000-26850000~~chr21:28625000-28650000,
chr21:28225000-28250000~~chr21:28625000-28650000,
chr21:28325000-28350000~~chr21:28625000-28650000,
chr21:28375000-28400000~~chr21:28625000-28650000,
chr21:28425000-28450000~~chr21:28625000-28650000,
chr21:28500000-28525000~~chr21:28625000-28650000,
chr21:28521313-28523242~~chr21:28643788-28645721,
chr21:28525000-28550000~~chr21:28625000-28650000,
chr21:28625000-28650000~~chr21:28725000-28750000,