- Basic information
- CohesinDB ID: CDBP00415597
- Locus: chr21-26938947-26942644
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Data sourse: ENCSR000HPG, ENCSR917QNE, GSE206145, GSE152721, GSE206145-NatGen2015, GSE116344, GSE165895
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Cell type: RPE, Fibroblast, RH4, IMR-90, Liver, HAP1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
40% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 43%,
"5_TxWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: CEBPB, OGG1, HNF1A, TP53, HNF1B, ELF3
- Target gene symbol (double-evidenced CRMs): ADAMTS5,JAM2,ADAMTS1
- Function elements
- Human SNPs: Waist_circumference_adjusted_for_body_mass_index
- Number of somatic mutations (coding): 32
- Number of somatic mutations (non-coding): 26
- Related genes and loops
- Related gene:
ENSG00000154721,
ENSG00000154734,
ENSG00000154736,
- Related loop:
chr21:17450000-17475000~~chr21:26925000-26950000,
chr21:25650000-25675000~~chr21:26925000-26950000,
chr21:26825000-26850000~~chr21:26925000-26950000,
chr21:26925000-26950000~~chr21:27100000-27125000,
chr21:26925000-26950000~~chr21:27200000-27225000,
chr21:26925000-26950000~~chr21:27300000-27325000,
chr21:26925000-26950000~~chr21:27375000-27400000,
chr21:26925000-26950000~~chr21:27550000-27575000,
chr21:26932823-26934519~~chr21:26951979-26953930,
chr21:26939108-26940527~~chr21:27589432-27591275,