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Basic information

CohesinDB ID: CDBP00415334

Locus: chr21-25895168-25897778

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE126634, GSE165895, ENCSR000EGW, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, ENCSR330ELC, GSE108869, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE139435, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE115250, GSE138405, GSE93080, GSE76893, GSE101921, GSE135093, GSE152721, GSE120943, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, ENCSR895JMI, ENCSR000EEG, GSE98367, ENCSR193NSH, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, GSE62063, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, ENCSR748MVX, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE131956, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, GSE155324, ENCSR000EDE, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, CVI-hiPSC, Liver, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, Ramos, GM19238, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 48% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.289

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 57%, "4_Tx": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, CBX5, PGR, LCORL, MEIS2, XBP1, FOXA1, PBX2, HNRNPK, ATF3, NFIC, ZNF362, ZBTB44, CHD7, TP63, ZNF467, MYOG, ELF1, BCLAF1, TRIM28, TEAD1, ESR1, ZFP91, CTCF, JUN, BAF155, IRF4, RFX5, SMC1, TEAD4, PDX1, POU2F2, CHD8, POU5F1, TOP2A, RUNX1T1, STAT1, ZNF205, SRF, DDX5, ARID3A, HOXC5, ERG, OGG1, MYC, SMARCA4, RAD21, RXRA, GABPA, STAT3, NKX3-1, RCOR1, DACH1, CEBPB, CREB1, EZH2, EBF3, ZHX2, SPI1, GATA2, FLI1, RELB, MRTFB, NCOA2, RUNX1, MAFG, SMC1A, CBX1, NKX2-2, POU4F2, SMAD3, ZNF654, TRIM22, SMARCC1, ZBTB2, RUNX2, GATA4, ZNF184, ARNT, NFIB, ATF2, HMBOX1, PBX3, MAFB, FOS, CDK8, MED1, CEBPD, PIAS1, SMAD1, C11orf30, RBM22, MAFK, SP1, BCL11A, REST, ZBTB7A, POU2F3, ATF7, FOXP1, SMC3, STAG1, STAG2, FOXA2, EBF1, MEIS1, PAF1, GTF2B, MAFF, CDK9, HOXB13, YY1, RELA, JUNB, ISL1, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, AGO2, HAND2, KLF4, CEBPG, SP7, GFI1B, NCOA3, TCF7L2, TP53, PKNOX1, ZNF334, ZSCAN22, PHOX2B, ELF3, BHLHE40, AR, ZBTB16, NOTCH3, BRD4, TBX2, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): APP,CYYR1,MRPL39,ADAMTS1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 280

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000154719, ENSG00000142192, ENSG00000166265, ENSG00000154734,

eachgene

Deatailed information for cohesin site CDBP00415334