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Basic information

CohesinDB ID: CDBP00415953

Locus: chr21-28439119-28440662

Data sourse: GSE206145-NatGen2015, ENCSR000EHX, GSE165895

Cell type: Fibroblast, SK-N-SH, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 36% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 73%, "7_Enh": 13%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, SOX2, XBP1, FOXA1, TFAP4, NFIC, CHD7, MITF, ZNF573, ETV1, ESR1, MED26, JUN, TCF12, BAF155, EP300, TEAD4, PDX1, NANOG, MYCN, BRD3, TOP2A, ERF, DUX4, HNF4G, ERG, HOXC5, ASCL1, MYC, RAD21, GRHL3, RXRA, GABPA, STAT3, NKX3-1, RCOR1, ARNTL, NR3C1, CEBPB, CREB1, EZH2, GRHL2, EBF3, ZHX2, EHF, HDAC2, GATA2, MXI1, RUNX1, SMC1A, SIN3A, SMAD3, SMARCC1, ZNF384, RUNX2, GATA4, GR, PBX4, DAXX, NRF1, ARNT, ATF2, PRDM9, PBX3, CHD1, FOS, MED1, PIAS1, MAFK, HNF4A, REST, ARID1A, ATF7, ASH2L, FOXP1, ZNF283, PPARG, FOXA2, ZSCAN16, ESR2, FOXF1, HOXB13, YY1, RELA, JUNB, BRG1, ISL1, HIF1A, OTX2, GATA3, TAL1, MAX, HAND2, TLE3, NCOA3, TCF7L2, NEUROG2, MYOD1, PHOX2B, ELF3, BRD2, BHLHE40, AR, BRD4, JUND, SCRT1, ZNF440, TBX2, FOSL2

Target gene symbol (double-evidenced CRMs): CYYR1,ADAMTS1,LINC00113

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 8

Related genes and loops

Related gene: ENSG00000166265, ENSG00000154734, ENSG00000225298,

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Deatailed information for cohesin site CDBP00415953