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Basic information

CohesinDB ID: CDBP00415704

Locus: chr21-27371620-27373080

Data sourse: ENCSR000EFJ, GSE138405, ENCSR000HPG, ENCSR404BPV, GSE206145, ENCSR000EDE, GSE68388, GSE126990, GSE165895

Cell type: RPE, Hela-Kyoto, Neurons-H1, HeLa-S3, IMR-90, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 36% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 68%, "7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, ZNF283, SMARCA2, ZNF496, FOXA2, MYCN, POU5F1, DUX4, FOXA1, FOXF1, HOXB13, TWIST1, SMARCC1, ERG, PAX6, RELA, ZNF792, NEUROD1, JUNB, RUNX2, MYC, GATA4, EOMES, RAD21, LHX2, CHD7, RXRA, OTX2, GATA3, BATF3, STAT3, PBX3, MAX, FOS, GATA1, NFE2, MED1, NR3C1, CEBPB, NR2F2, TEAD1, ETV1, NFE2L2, TP53, TBX5, JUN, TCF12, MAFK, SP1, EP300, BHLHE40, GATA6, NKX2-5, GATA2, REST, YAP1, ZNF777, MXI1, BRD4, JUND, TEAD4

Target gene symbol (double-evidenced CRMs): ADAMTS5,ADAMTS1

Function elements

Human SNPs: Dialysis-related_mortality

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 16

Related genes and loops

Related gene: ENSG00000154734, ENSG00000154736,

eachgene

Deatailed information for cohesin site CDBP00415704